info:eu-repo/semantics/article
In vitro studies of cellular response to DNA damage induced by boron neutron capture therapy
Fecha
2011-12Registro en:
Perona, Marina; Pontiggia, Osvaldo Alejandro; Carpano, Marina; Thomasz, Lisa; Thorp, Silvia Inés; et al.; In vitro studies of cellular response to DNA damage induced by boron neutron capture therapy; Pergamon-Elsevier Science Ltd; Applied Radiation and Isotopes; 69; 12; 12-2011; 1732-1736
0969-8043
CONICET Digital
CONICET
Autor
Perona, Marina
Pontiggia, Osvaldo Alejandro
Carpano, Marina
Thomasz, Lisa
Thorp, Silvia Inés
Pozzi, Emiliano César Cayetano
Simian, Marina
Kahl, S.
Juvenal, Guillermo Juan
Pisarev, Mario Alberto
Dagrosa, María Alejandra
Resumen
The aim of these studies was to evaluate the mechanisms of cellular response to DNA damage induced by BNCT. Thyroid carcinoma cells were incubated with 10BPA or 10BOPP and irradiated with thermal neutrons. The surviving fraction, the cell cycle distribution and the expression of p53 and Ku70 were analyzed. Different cellular responses were observed for each irradiated group. The decrease of Ku70 in the neutrons +BOPP group could play a role in the increase of sensitization to radiation.