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Comparative analysis reveals amino acids critical for anticancer activity of peptide CIGB-552
(John Wiley & Sons Ltd, 2016-11)
Because of resistance development by cancer cells against current anticancer drugs, there is a considerable interest in developing novel antitumor agents. We have previously demonstrated that CIGB-552, a novel cell-penetrating ...
Broken Rice as a Potential Functional Ingredient with Inhibitory Activity of Renin and Angiotensin-Converting Enzyme (ACE)
(Springer, 2019-07)
The aim of this work was to evaluate the ability of broken rice, an underutilized industrial by-product, as a potential functional and health promoting ingredient. With this purpose, the ability to inhibit the angiotensin ...
Identification of the cognate peptide-MHC target of T cell receptors using molecular modeling and force field scoring
(Pergamon-Elsevier Science Ltd, 2018-02)
Interactions of T cell receptors (TCR) to peptides in complex with MHC (p:MHC) are key features that mediate cellular immune responses. While MHC binding is required for a peptide to be presented to T cells, not all MHC ...
Amaranth peptides decreased the activity and expression of cellular tissue factor on LPS activated THP-1 human monocytes
(Royal Society of Chemistry, 2018-07)
The effect of amaranth peptides on the activity and expression of tissue factor (TF) on THP-1 activated cells was evaluated in vitro. An active anticoagulant peptide fraction (AF) was found to inhibit TF expression (IC50 ...
Latest Advances in OBOC Peptide Libraries: Improvements in Screening Strategies and Enlarging the Family From Linear to Cyclic Libraries
(Bentham Science Publishers, 2016-03)
Solid phase screenings of one bead one compound (OBOC) libraries have been widely used to find ligands with pharmacological and analytical uses, and to purify or detect proteins in complex mixtures. To improve library ...
BR-bombesin: a novel bombesin-related peptide from the skin secretion of the Chaco tree frog (Boana raniceps) with physiological gastric effects
(Springer, 2022-03-13)
Bombesin mediates several biological activities in the gastrointestinal (GI) tract and central nervous system in mammals, including smooth muscle contraction, secretion of GI hormones and regulation of homeostatic mechanisms. ...
Proteomics Data Analysis for the Identification of Proteins and Derived Proteotypic Peptides of Potential Use as Putative Drought Tolerance Markers for Quercus ilex
(MDPI, 2021-03)
Drought is one of the main causes of mortality in holm oak (Quercus ilex) seedlings used in reforestation programs. Although this species shows high adaptability to the extreme climate conditions prevailing in Southern ...
Biological activity of antibacterial peptides matches synergism between electrostatic and non electrostatic forces
(Elsevier Science, 2014-07)
Substitution of Ala 108 and Ala 111 in the 107–115 human lysozyme (hLz) fragment results in a 20- fold increased anti-staphylococcal activity while its hemolytic activity becomes significant (30%) at very high concentrations. ...
New small-size peptides possessing antifungal activity
(Elsevier, 2010-01)
The synthesis, in vitro evaluation, and conformational study of a new series of small-size peptides acting as antifungal agents are reported. In a first step of our study we performed a conformational analysis using Molecular ...