info:eu-repo/semantics/article
New small-size peptides possessing antifungal activity
Fecha
2010-01Registro en:
Garibotto, Francisco Matías; Garro, Adriana; Masman, Marcelo Fabricio; Rodriguez, Ana Maria; Luiten, Paul G. M.; et al.; New small-size peptides possessing antifungal activity; Elsevier; Bioorganic & Medicinal Chemistry; 18; 1; 1-2010; 158-167
0968-0896
CONICET Digital
CONICET
Autor
Garibotto, Francisco Matías
Garro, Adriana
Masman, Marcelo Fabricio
Rodriguez, Ana Maria
Luiten, Paul G. M.
Raimondi, Marcela Patricia
Zacchino, Susana Alicia Stella
Somlai, Csaba
Penke, Botond
Enriz, Ricardo Daniel
Resumen
The synthesis, in vitro evaluation, and conformational study of a new series of small-size peptides acting as antifungal agents are reported. In a first step of our study we performed a conformational analysis using Molecular Mechanics calculations. The electronic study was carried out using Molecular electrostatic potentials (MEPs) obtained from RHF/6-31G calculations. On the basis of the theoretical predictions three small-size peptides, RQWKKWWQWRR-NH2, RQIRRWWQWRR-NH2, and RQIRRWWQW-NH2 were synthesized and tested. These peptides displayed a significant antifungal activity against human pathogenic strains including Candida albicans and Cryptococcus neoformans. Our experimental and theoretical results allow the identification of a topographical template which can serve as a guide for the design of new compounds with antifungal properties for potential therapeutic applications against these pathogenic fungi.