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Mostrando ítems 141-149 de 149
Profiling Lgals9 splice variant expression at the fetal-maternal interface: implications in normal and pathological human pregnancy
(Oxford University Press, 2013)
Disruption of fetal-maternal tolerance mechanisms can contribute to pregnancy complications, including spontaneous abortion. Galectin-9 (LGALS9), a tandem repeat lectin associated with immune modulation, is expressed in ...
Editorial: Addressing roles for glycans in immunology using chemical biology
(Frontiers Media S.A., 2020-06)
Glycoconjugates, macromolecules containing carbohydrates (glycans) conjugated to proteins or lipids, are a diverse class of biopolymers capable of regulating cell-cell interactions. They are present in a high, natural ...
Secreted factors by Anaplastic Thyroid Cancer Cells Induce Tumor-Promoting M2-like Macrophage Polarization through a TIM3-Dependent Mechanism
(Multidisciplinary Digital Publishing Institute, 2021-10)
Anaplastic thyroid cancer (ATC) is a highly aggressive type of thyroid cancer (TC). Currently, no effective target treatments are available that can improve overall survival, with ATC representing a major clinical challenge ...
Oligonucleotide IMT504 improves glucose metabolism and controls immune cell mediators in female diabetic NOD mice
(Mary Ann Liebert, 2021-04)
Type 1 diabetes occurs as a consequence of progressive autoimmune destruction of beta cells. A potential treatment for this disease should address the immune attack on beta cells and their preservation/regeneration. The ...
Microbially driven TLR5-dependent signaling governs distal malignant progression through tumor-promoting inflammation
(Cell Press, 2015-01-12)
The dominant TLR5(R392X) polymorphism abrogates flagellin responses in >7% of humans. We report that TLR5-dependent commensal bacteria drive malignant progression at extramucosal locations by increasing systemic IL-6, which ...
Satb1 overexpression drives tumor-promoting activities in cancer-associated dendritic cells
(Cell Press, 2016-02-11)
Special AT-rich sequence-binding protein 1 (Satb1) governs genome-wide transcriptional programs. Using a conditional knockout mouse, we find that Satb1 is required for normal differentiation of conventional dendritic cells ...
Glycosylation-dependent lectin-receptor interactions preserve angiogenesis in anti-VEGF refractory tumors
(Cell Press, 2014-02-13)
The clinical benefit conferred by vascular endothelial growth factors (VEGF)-targeted therapies is variable, and tumors from treated patients eventually reinitiate growth. Here, we identify a glycosylation-dependent pathway ...
The Role of the Interleukin-17 Axis and Neutrophils in the Pathogenesis of Endemic and Systemic Mycoses
(Frontiers MediaGrupo de Investigación en Microbiología Básica y Aplicada-MicrobaGrupo Tándem Max Planck en NanobioingenieríaMicología Médica y ExperimentalLausana, Suiza, 2022)