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Evaluation of the immune response to Anaplasma marginale MSP5 protein using a HSV-1 amplicon vector system or recombinant protein
(2014-12)
Anaplasma marginale is an intraerythrocytic vector-borne infectious agent of cattle. Immunization with the current vaccine, based on parasitized erythrocytes with live Anaplasma centrale, shows some constraints and confers ...
Effects of the liposomal co-encapsulation of antigen and PO-CpG oligonucleotide on immune response in mice
(International Journal for Research, 2017-06)
The development of novel vaccines requires the design of new adjuvants able to give long lasting immune responses. Our aim was to obtain cationic liposomes as adjuvants by an industry-suitable method, and evaluate them ...
Assessment of trade-offs between simultaneous immune challenges in a slow-living subterranean rodent
(University of Chicago Press, 2019-01)
The coexistence of two or more infectious agents in the same host is common in nature. Given this, the study of trade-offs within the immune system itself is key to understanding how immune defenses act in wild species in ...
Thyroid hormone modulation of immunity: Its participation in chronic stress-induced immune alterations
(Bentham Science Publishers, 2009-10)
The interaction between the immune and the neuroendocrine systems involves, in a bidirectional circuit, shared cellular receptors and their coupled signaling pathways. Disruptions of this circuit lead to pathological ...
The role of extracellular nucleic acids in the immune system modulation of Rhodnius prolixus (Hemiptera: Reduviidae)
(Academic Press Inc Elsevier Science, 2020-04)
Extracellular traps (ETs) are extracellular nucleic acids associated with cytoplasmic proteins that may aid in the capture and killing of pathogens. To date, only a few insects were shown to display this kind of immune ...
Unveiling the immune infiltrate modulation in cancer and response to immunotherapy by MIXTURE—an enhanced deconvolution method
(Oxford University Press, 2020-12-16)
The accurate quantification of tumor-infiltrating immune cells turns crucial to uncover their role in tumor immune escape, to determine patient prognosis and to predict response to immune checkpoint blockade. Current ...
Immunization with Tc52 or its amino terminal domain adjuvanted with c-di-AMP induces Th17+Th1 specific immune responses and confers protection against Trypanosoma cruzi
(Public Library of Science, 2017-02)
The development of new adjuvants enables fine modulation of the elicited immune responses. Ideally, the use of one or more adjuvants should result in the induction of a protective immune response against the specific ...
Daily very low UV dose exposure enhances adaptive immunity, compared with a single high‐dose exposure. Consequences for the control of a skin infection
(Wiley Blackwell Publishing, Inc, 2018-07)
Ultraviolet radiation (UVr) promotes several well‐known molecular changes, which may ultimately impact on health. Some of these effects are detrimental, like inflammation, carcinogenesis and immunosuppression. On the other ...
Nasal immunization with Lactococcus lactis expressing the pneumococcal protective protein A induces protective immunity in mice
(American Society for Microbiology, 2008-06)
Nisin-controlled gene expression was used to develop a recombinant strain of Lactococcus lactis that is able to express the pneumococcal protective protein A (PppA) on its surface. Immunodetection assays confirmed that ...
Babesia bovis AMA-1, MSA-2c and RAP-1 contain conserved B and T-cell epitopes, which generate neutralizing antibodies and a long-lasting Th1 immune response in vaccinated cattle
(Elsevier, 2022-02)
Vaccines against bovine babesiosis must, ideally, induce a humoral immune response characterized by neutralizing antibodies against conserved epitopes and a cellular Th1 immune response. In Babesia bovis, proteins such as ...