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Early ethanol pre-exposure alters breathing patterns by disruptions in the central respiratory network and serotonergic balance in neonate rats
(Elsevier Science, 2021-01)
Early ethanol exposure alters neonatal breathing plasticity. Respiratory EtOH's effects are attributed to central respiratory network disruptions, particularly in the medullary serotonin (5HT) system. In this study we ...
ELSA cohort 2014: Association of age of first drink and progression from first drink to drunkenness on alcohol outcomes in Argentinean college freshmen
(Taylor & Francis, 2019-05)
College freshman are at-risk for hazardous alcohol drinking and for experiencing alcohol-related negative consequences. This is exacerbated in those featuring an early age of first alcohol use or of first drunkenness. It ...
Influence of HIV Infection and Antiretroviral Therapy on Bone Homeostasis
(Frontiers Research Foundation, 2020-09-02)
The human immunodeficiency virus type 1 (HIV)/AIDS pandemic represents the most significant global health challenge in modern history. This infection leads toward an inflammatory state associated with chronic immune ...
State interventions and COVID-19
(Universidad Católica Silva Henríquez, 2021-07)
In view of all the measures taken by the State, understood as publicpolicies, as well as the particular circumstances in the region that havebeen exacerbated by COVID-19, the role of the State and its actions areopen to ...
Tuberculosis-associated IFN-I induces Siglec-1 on tunneling nanotubes and favors HIV-1 spread in macrophages
(eLife Sciences Publications Ltd, 2020-03)
While tuberculosis (TB) is a risk factor in HIV-1-infected individuals, the mechanisms by which Mycobacterium tuberculosis (Mtb) worsens HIV-1 pathogenesis remain scarce. We showed that HIV-1 infection is exacerbated in ...
Trophoblast cells inhibit neutrophil extracellular trap formation and enhance apoptosis through vasoactive intestinal peptide-mediated pathways
(Oxford University Press, 2016-12)
STUDY QUESTION:Do human trophoblast cells modulate neutrophil extracellular trap (NET) formation, reactive oxygen species (ROS) synthesis and neutrophil apoptosis through mechanisms involving vasoactive intestinal peptide ...
Trypanosoma cruzi Infection Is a Potent Risk Factor for Non-alcoholic Steatohepatitis Enhancing Local and Systemic Inflammation Associated with Strong Oxidative Stress and Metabolic Disorders
(Public Library of Science, 2015-02)
The immune mechanisms underlying experimental non-alcoholic steatohepatitis (NASH), and more interestingly, the effect of T. cruzi chronic infection on the pathogenesis of this metabolic disorder are not completely understood. ...
Osmotic stress induces apoptosis in extravillous trophoblast cells. Role of TRPV-1
(Academic Press Inc Elsevier Science, 2019-06)
In different tissues hyperosmolarity induces cell differentiation. Nevertheless an exacerbated hyperosmolar stress alters the normal cellular development. The transient receptor potential vanilloid 1 (TRPV-1) is a non-selective ...
The role of regulatory T Cells in autoimmune orchitis
(Wiley Blackwell Publishing, Inc, 2018-12)
Regulatory T cells (Tregs) mediate tolerance to self-antigens maintaining immune homeostasis. Defects in the number and function of Tregs lead to aberrant immune responses to autologous components, thereby causing autoimmune ...
Assessing the uneven global distribution of readership, submissions and publications in applied ecology: Obvious problems without obvious solutions
(Wiley Blackwell Publishing, Inc, 2019-01)
What do Colombia, Indonesia, and Papua New Guinea have in common? Not only are they among the most biodiverse countries in the world, they also face a suite of environmental problems relating to land‐use intensification, ...