info:eu-repo/semantics/article
Osmotic stress induces apoptosis in extravillous trophoblast cells. Role of TRPV-1
Fecha
2019-06Registro en:
Reppetti, Julieta; Etcheverry, Tomás; Sierra, Matías N.; Damiano, Alicia Ermelinda; Farina, Mariana; et al.; Osmotic stress induces apoptosis in extravillous trophoblast cells. Role of TRPV-1; Academic Press Inc Elsevier Science; Biochemical and Biophysical Research Communications; 514; 1; 6-2019; 58-63
0006-291X
CONICET Digital
CONICET
Autor
Reppetti, Julieta
Etcheverry, Tomás
Sierra, Matías N.
Damiano, Alicia Ermelinda
Farina, Mariana
Martinez, Nora Alicia
Resumen
In different tissues hyperosmolarity induces cell differentiation. Nevertheless an exacerbated hyperosmolar stress alters the normal cellular development. The transient receptor potential vanilloid 1 (TRPV-1) is a non-selective cation channel that is activated by hyperosmolarity and participates in many cellular processes. TPRV-1 is expressed in human placenta at term. Here, we evaluated the expression of TRPV-1 in first trimester extravillous trophoblast cells and its participation in the survival of these cells exposed to hyperosmolar stress. Our results showed that hyperosmolar stress up-regulates the expression of TRPV-1 and induces the apoptosis in Swan 71 cells. In addition, the inhibition of TRPV-1 abrogates the apoptotic events.