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The relative fitness of drug-resistant Mycobacterium tuberculosis: a modelling study of household transmission in Peru
(Royal Society Publishing, 2018)
The relative fitness of drug-resistant versus susceptible bacteria in an environment dictates resistance prevalence. Estimates for the relative fitness of resistant Mycobacterium tuberculosis (Mtb) strains are highly ...
Molecular and phenotypic characterisation of Mycobacterium tuberculosis resistant to anti-tuberculosis drugs
(International Union Against Tuberculosis and Lung Disease, 2013-08)
SETTING: Dr Cetrángolo Hospital, Buenos Aires, Argentina. OBJECTIVES: To characterise drug-resistant (DR), multidrug-resistant (MDR-) and extensively drug-resistant (XDR-) Mycobacterium tuberculosis isolates, and identify ...
Evaluation of the broth microdilution plate methodology for susceptibility testing of Mycobacterium tuberculosis in Peru
(BioMed Central, 2022)
Background: Tuberculosis (TB) is a communicable, preventable and curable disease caused by the bacterium Mycobacterium tuberculosis (MTB). Peru is amongst the 30 countries with the highest burden of multidrug-resistant ...
Convergent evolution and topologically disruptive polymorphisms among multidrug-resistant tuberculosis in Peru
(Public Library of Science, 2017)
BACKGROUND: Multidrug-resistant tuberculosis poses a major threat to the success of tuberculosis control programs worldwide. Understanding how drug-resistant tuberculosis evolves can inform the development of new therapeutic ...
Caracterización de Escherichia coli D7111 productora de β-lactamasa TEM-176
(Instituto Nacional de Salud, 2021)
The present report is the original description of blaTEM-176. The mechanisms of resistance to antimicrobial agents were determined in an enterotoxigenic Escherichia coli, determining the susceptibility to 22 antimicrobials ...
Drug transfer into target helminth parasites
(Elsevier, 2007-03)
The pharmacokinetics of an anthelmintic drug includes the time course of drug absorption, distribution, metabolism and elimination from the host and determines the concentration of the active drug that reaches the location ...
Prevalence, Risk Factors, and Treatment Outcomes of Isoniazid- and Rifampicin-Mono-Resistant Pulmonary Tuberculosis in Lima, Peru
(Public Library of Science, 2016)
BACKGROUND: Isoniazid and rifampicin are the two most efficacious first-line agents for tuberculosis (TB) treatment. We assessed the prevalence of isoniazid and rifampicin mono-resistance, associated risk factors, and the ...
Overcoming drug resistance with on-demand charged thermoresponsive dendritic nanogels
(Future Medicine, 2016-11-23)
To develop nanogels (NG) able to modulate the encapsulation and release of drugs, in order to circumvent drug resistance mechanisms in cancer cells. Materials & methods: Poly-N-isopropylacrylamide-dendritic polyglycerol ...
Prevalence of Antimicrobial Resistance in Bacterial Isolates from Dogs and Cats in a Veterinary Diagnostic Laboratory in Colombia from 2016–2019
(MDPICentro de Investigaciones Básicas y Aplicadas en Veterinaria (CIBAV)Basilea, Suiza, 2022)