info:eu-repo/semantics/article
Overcoming drug resistance with on-demand charged thermoresponsive dendritic nanogels
Fecha
2016-11-23Registro en:
Molina, María Alejandra; Wedepohl, Stefanie; Miceli, Enrico; Calderon, Marcelo; Overcoming drug resistance with on-demand charged thermoresponsive dendritic nanogels; Future Medicine; Nanomedicine; 12; 2; 23-11-2016; 117-129
1743-5889
1748-6963
CONICET Digital
CONICET
Autor
Molina, María Alejandra
Wedepohl, Stefanie
Miceli, Enrico
Calderon, Marcelo
Resumen
To develop nanogels (NG) able to modulate the encapsulation and release of drugs, in order to circumvent drug resistance mechanisms in cancer cells. Materials & methods: Poly-N-isopropylacrylamide-dendritic polyglycerol NG were semi-interpenetrated with 2-acrylamido-2-methylpropane sulfonic acid or (2- dimethylamino) ethyl methacrylate. Physico-chemical properties of the NGs as well as doxorubicin (DOXO) loading and release were characterized. Drug delivery performance was investigated in vitro and in vivo in a multidrug-resistant tumor model. Both the DOXO loaded semi-interpenetrating polymer network NGs were more efficient in multidrug resistant cancer cell proliferation inhibition studies. In vivo, the DOXO loaded NG semi-interpenetrated with 2-acrylamido-2-methylpropane sulfonic acid was able to overcome drug resistance and reduce the tumor volume to about 25%. The innovative semi-interpenetrating polymer network NGs appear to be promising drug carriers for drug resistant cancer therapy.