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Isoform Selectivity of Adenylyl Cyclase Inhibitors: Characterization of Known and Novel Compounds
(American Society For Pharmacology And Experimental Therapeutics, 2013-11)
Nine membrane-bound adenylyl cyclase (AC) isoforms catalyze the production of the second messenger cyclic AMP (cAMP) in response to various stimuli. Reduction of AC activity has well documented benefits, including benefits ...
On the interaction of sustrate analogues with non-phosphorylating glyceraldehydes-3-phosphate dehydrogenase from celery leaves
(Elsevier Ireland, 2002-01)
Structural analogues of D-glyceraldehyde-3-phosphate (D-Ga3P) and NADP+ were studied as potential substrates and inhibitors of the non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.9; GAPN) from Apium ...
Structural determinants of efficacy at A3 adenosine receptors: Modification of the ribose moiety
(Pergamon-Elsevier Science Ltd, 2004-03)
We have found previously that structural features of adenosine derivatives, particularly at the N6- and 2-positions of adenine, determine the intrinsic efficacy as A3 adenosine receptor (AR) agonists. Here, we have probed ...
Splice variant rs72613567 prevents worst histologic outcomes in patients with nonalcoholic fatty liver disease
(American Society for Biochemistry and Molecular Biology, 2018-10)
Hydroxysteroid 17-β dehydrogenase 13 (HSD17B13) is a lipid droplet-associated protein; its gene-encoding variants affect the chronic liver diseases, including nonalcoholic fatty liver disease (NAFLD). To estimate the effect ...
In vitro propagation of Carica papaya var. PTM-331 from apical meristemPropagación in vitro de Carica papaya var. PTM-331 a partir de meristemos apicales
(Universidad Nacional Mayor de San Marcos, Facultad de Ciencias Biológicas, 2011)
A facile one-pot synthesis of 8-oxo-7,8-dihydro-(2′-deoxy)adenosine in water
(Pergamon-Elsevier Science Ltd, 2006-01)
Reaction of 2-mercaptoethanol with 8-bromo-2′-deoxyadenosine and 8-bromo-adenosine in aqueous solution and in the presence of triethylamine gave the 8-oxo-adenine derivatives in very good yields. Some mechanistic details ...
Amperometric detection of D-sorbitol with NAD+-D-sorbitol dehydrogenase modified carbon paste electrode
(Elsevier Science, 2000-11)
A biosensor based on modified carbon paste electrodes for the amperometric detection of D-sorbitol is described. Carbon paste electrodes were modified by D-sorbitol dehydrogenase (SDH) and nicotinamide adenine dinucleotide ...
In vitro propagation and stoloniferous stem formation of Thelesperma megapotamicum
(Instituto de Investigación de las Ciencias Exactas Físicas y Naturales, 2010-04)
An efficient “in vitro” propagation protocol for Thelesperma megapotamicum (Spreng.) Kuntnze was established. Nodal segments were cultured in vitro with different combination and concentration of growth regulators. Microshoots ...
Nox2 upregulation and p38α mapk activation in right ventricular hypertrophy of rats exposed to long-term chronic intermittent hypobaric hypoxia
(MDPI, 2020)
One of the consequences of high altitude (hypobaric hypoxia) exposure is the development of right ventricular hypertrophy (RVH). One particular type of exposure is long-term chronic intermittent hypobaric hypoxia (CIH); ...