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The involvement of transition metal ions on iron-dependent lipid peroxidation
(Springer, 2010-04)
The metals iron (Fe) and copper (Cu) are considered trace elements, and the metals cobalt (Co) and nickel (Ni) are known as ultra-trace elements, considering their presence in low to very low quantity in humans. The biologic ...
Detecting phospholipase activity with the amphipathic lipid packing sensor motif of ArfGAP1
(Academic Press Inc Elsevier Science, 2018-10)
The amphipathic lipid packing sensor (ALPS) motif of ArfGAP1 brings this GTPase activating protein to membranes of high curvature. Phospholipases are phospholipid-hydrolyzing enzymes that generate different lipid products ...
The integrity of the α-helical domain of intestinal fatty acid binding protein is essential for the collision-mediated transfer of fatty acids to phospholipid membranes
(Elsevier Science, 2008-04)
Intestinal FABP (IFABP) and liver FABP (LFABP), homologous proteins expressed at high levels in intestinal absorptive cells, employ markedly different mechanisms of fatty acid transfer to acceptor model membranes. Transfer ...
Procyanidins can interact with Caco-2 cell membrane lipid rafts: involvement of cholesterol
(Elsevier Science, 2013-11)
Large procyanidins (more than three subunits) are not absorbed at the gastrointestinal tract but could exert local effects through their interactions with membranes. We previously showed that hexameric procyanidins (Hex), ...
Editorial: Emerging Mechanisms in Neuronal Signaling: From Cell Biology to Pathogenesis
(Frontiers Media S.A., 2020-08-31)
Unraveling the molecular processes involved in the genesis, differentiation, and cell death of the nervous system is an intense and continual interest of the neuroscience community. In recent years, the preponderance of ...
LRP1-Mediated AggLDL endocytosis promotes pholesteryl ester accumulation and impairs insulin response in HL-1 cells
(MDPI, 2020-01)
The cardiovascular disease (CVD) frequently developed during metabolic syndrome and type-2 diabetes mellitus is associated with increased levels of aggregation-prone small LDL particles. Aggregated LDL (aggLDL) internalization ...
The interplay between viperin antiviral activity, lipid droplets and Junín mammarenavirus multiplication
(Academic Press Inc Elsevier Science, 2018-01)
Junín arenavirus infections are associated with high levels of interferons in both severe and fatal cases. Upon Junín virus (JUNV) infection a cell signaling cascade initiates, that ultimately attempts to limit viral ...
Brown Fat AKT2 Is a Cold-Induced Kinase that Stimulates ChREBP-Mediated De Novo Lipogenesis to Optimize Fuel Storage and Thermogenesis
(Cell Press, 2018-01)
Brown adipose tissue (BAT) is a therapeutic target for metabolic diseases; thus, understanding its metabolic circuitry is clinically important. Many studies of BAT compare rodents mildly cold to those severely cold. Here, ...