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Enkephalin is essential for the molecular and behavioral expression of cocaine sensitization
(Wiley, 2014-11)
Behavioral sensitization to cocaine is associated to neuroadaptations that contribute to addiction. Enkephalin is highly expressed in mesocorticolimbic areas associated with cocaine-induced sensitization; however, their ...
Memantine agonist action at dopamine D2High receptors
(Veterinary and Human Toxicology, 2008-02)
Memantine is reported to improve symptoms in moderate cases of Alzheimer´s disease and Parkinson´s disease, but is also known to trigger psychosis in some Parkinson patients. Because these clinical features suggested a ...
Microglial glutamate release evoked by α-synuclein aggregates is prevented by dopamine
(Wiley-liss, div John Wiley & Sons Inc., 2018-11)
When activated, microglial cells have the potential not only to secrete typical proinflammatory mediators but also to release the neurotransmitter glutamate in amounts that may promote excitotoxicity. Here, we wished to ...
Contributions of dopaminergic signaling to timing accuracy and precision
(Elsevier, 2016-04)
Existing evidence suggests that interval timing, processing of temporal information in the hundredth of milliseconds-to-minutes range, recruits broad brain regions such as cortico-striatal circuits via dopaminergic-glutamatergic ...
Minutes, days and years: molecular interactions among different scales of biological timing
(The Royal Society, 2014-01)
Biological clocks are genetically encoded oscillators that allow organisms to keep track of their environment. Among them, the circadian system is a highly conserved timing structure that regulates several physiological, ...
Putative dopamine neurons in the ventral tegmental area enhance information coding in the prefrontal cortex
(Nature Publishing Group, 2018-12)
It has been proposed that neuronal populations in the prefrontal cortex (PFC) robustly encode task-relevant information through an interplay with the ventral tegmental area (VTA). Yet, the precise computation underlying ...
Dopamine D2R DNA transfer in dopamine D2 receptor-deficient mice: Effects on ethanol drinking
(Pergamon-Elsevier Science Ltd, 2005-05)
Dopamine (DA) signals are transmitted via specific receptors including the D2 receptors (D2R). Previous studies have shown that D2R upregulation in the nucleus accumbens (NAc) attenuated alcohol consumption. We hypothesized ...