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Inter-generational consequences for growing Caenorhabditis elegans in liquid
(The Royal Society, 2019-04)
In recent years, studies in Caenorhabditis elegans nematodes have shown that different stresses can generate multigenerational changes. Here, we show that worms that grow in liquid media, and also their plate-grown progeny, ...
Synthesis of a deuterated standard for the quantification of 2-Arachidonoylglycerol in Caenorhabditis elegans
(Journal of Visualized Experiments, 2019-10)
This work presents a method to prepare an analytical standard to analyze 2-arachidonoyl glycerol (2-AG) qualitatively and quantitatively by liquid chromatography-electrospray Ionization-tandem mass spectrometry (LC-ESI-MS/MS). ...
Contribution of subunits to Caenorhabditis elegans levamisole-sensitive nicotinic receptor function
(American Society for Pharmacology and Experimental Therapeutics, 2012-09-25)
Caenorhabditis elegans muscle contains seven different nicotinic receptor (AChR) subunits, five of which have been shown to be components of adult levamisole-sensitive AChRs (L-AChRs). To elucidate the reason for such ...
The Caenorhabditis elegans DAF-12 nuclear receptor: Structure, dynamics, and interaction with ligands
(Wiley-liss, Div John Wiley & Sons Inc, 2012-07)
A structure for the ligand binding domain (LBD) of the DAF-12 receptor from Caenorhabditis elegans was obtained from the X-ray crystal structure of the receptor LBD from Strongyloides stercoralis bound to (25R)-Δ7-dafachronic ...
Dynamic SUMO modification regulates mitotic chromosome assembly and cell cycle progression in Caenorhabditis elegans
(Nature Publishing Group, 2014-12)
The small ubiquitin-like modifier (SUMO), initially characterized as a suppressor of a mutation in the gene encoding the centromeric protein MIF2, is involved in many aspects of cell cycle regulation. The dynamics of ...
CARACTERIZACIÓN DE LA TOXICIDAD DE HONGOS ALTERANTES DE ALIMENTOS UTILIZANDO CAENORHABDITIS ELEGANS
(Publitec, 2018-10)
Los alimentos representan una rica fuente de nutrientes para hongos filamentosos que, en condiciones óptimas, tienen un rápido desarrollo. Sin embargo, también son capaces de crecer frente a condiciones no favorables e ...
Synthesis and Biological Activity of Fluorinated Analogues of the DAF-12 Receptor Antagonist 24-Hydroxy-4-cholen-3-one
(Elsevier Science Inc, 2019-07)
The DAF-12 receptor is a ligand-activated transcription factor that in its ligand-bound form allows the expression of target genes needed to support the reproductive life cycle of the free-living nematode Caenorhabditis ...