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Hepatitis C Virus (HCV) clearance after treatment with direct-acting antivirals in human immunodeficiency virus (HIV)-HCV coinfection modulates systemic immune activation and HIV transcription on antiretroviral therapy
(Oxford University Press, 2020-05)
Background. Hepatitis C virus (HCV) coinfection among people with human immunodeficiency virus (HIV) might perturb immune function and HIV persistence. We aimed to evaluate the impact of HCV clearance with direct-acting ...
Hepatitis C Virus (HCV) Clearance After Treatment With Direct-Acting Antivirals in Human Immunodeficiency Virus (HIV)-HCV Coinfection Modulates Systemic Immune Activation and HIV Transcription on Antiretroviral Therapy
(Oxford University Press, 2020-05)
Background Hepatitis C virus (HCV) coinfection among people with human immunodeficiency virus (HIV) might perturb immune function and HIV persistence. We aimed to evaluate the impact of HCV clearance with direct-acting ...
Restimulation-induced T-cell death through NTB-A/SAP signaling pathway is impaired in tuberculosis patients with depressed immune responses
(Nature Publishing Group, 2017-09)
Production of IFN-γ3 contributes to host defense against Mycobacterium tuberculosis (Mtb) infection. We previously demonstrated that Signaling lymphocytic activation molecule-associated protein (SAP) expression on cells ...
Increased frequencies of activating natural killer receptors are associated with liver injury in individuals who do not eliminate hepatitis C virus
(Wiley Blackwell Publishing, Inc, 2007-12)
This study was designed to investigate the role of KIR genes in the outcome of HCV infection. In patients who cleared the virus (HCV RNA-) we found a decrease of 2DL2 (p=0.04), and 2DS2 (p=0.014) accompanied by an increase ...
Recent Advances in Understanding Immunity Against Brucellosis: Application for Vaccine Development
(Bentham Science Publishers, 2010-05)
Brucellosis is an important zoonotic disease of nearly worldwide distribution. This pathogen causes abortion in cattle and undulant fever, arthritis, endocarditis and meningitis in human. The immune response against B. ...
Blockade of Stat3 oncogene addiction induces cellular senescence and reveals a cell-nonautonomous activity suitable for cancer immunotherapy
(Taylor & Francis, 2020-01)
Stat3 is constitutively activated in several tumor types and plays an essential role in maintaining their malignant phenotype and immunosupression. To take advantage of the promising antitumor activity of Stat3 targeting, ...
Direct validation of NGcGM3 ganglioside as a new target for cancer immunotherapy
(Informa Healthcare, 2009-12)
OBJECTIVE: The target concept means not only an aberrant expression of a particular molecule in tumour tissues but also evidence of a clear therapeutic advantage, as a consequence of immune-intervention, in an antigen-positive ...
A deep dive into the pathology of gray platelet syndrome: new insights on immune dysregulation
(Dove Press, 2021-08)
The gray platelet syndrome (GPS) is a rare platelet disorder, characterized by impaired alpha-granule biogenesis in megakaryocytes and platelets due to NBEAL2 muta-tions. Typical clinical features include macrothrombocytopenia, ...
Evidence for shared molecular pathways of dysregulated decidualization in preeclampsia and endometrial disorders revealed by microarray data integration
(Federation of American Societies for Experimental Biology, 2019-11)
Microarray data of chorionic villous samples (CVSs) obtained from women of ~11.5 gestational weeks who developed preeclampsia with severe features (sPE; PE-CVS) revealed a molecular signature of impaired endometrial ...
Analogues of Human Granulysin as Antimycobacterial Agents
(Springer, 2019-06)
Antimicrobial peptides are essential components of innate defense mechanisms and make promising candidates for novel anti-infective agents. The advantages of these peptides in clinical applications include their potential ...