info:eu-repo/semantics/article
Increased frequencies of activating natural killer receptors are associated with liver injury in individuals who do not eliminate hepatitis C virus
Fecha
2007-12Registro en:
Paladino, Natalia; Flores, Ana Claudia; Marcos, Cintia Yanina; Fainboim, Hugo; Theiler, Gerardo Raul; et al.; Increased frequencies of activating natural killer receptors are associated with liver injury in individuals who do not eliminate hepatitis C virus; Wiley Blackwell Publishing, Inc; Tissue Antigens; 69; SUPPL. 1; 12-2007; 109-111
0001-2815
CONICET Digital
CONICET
Autor
Paladino, Natalia
Flores, Ana Claudia
Marcos, Cintia Yanina
Fainboim, Hugo
Theiler, Gerardo Raul
Arruvito, Maria Lourdes
Williams, F.
Middleton, D.
Fainboim, Leonardo
Resumen
This study was designed to investigate the role of KIR genes in the outcome of HCV infection. In patients who cleared the virus (HCV RNA-) we found a decrease of 2DL2 (p=0.04), and 2DS2 (p=0.014) accompanied by an increase of 2DS5 (p=0.04). Those RNA+ patients with elevated levels of hepatic transaminases (HCV RNA+ elevatedALT) showed an increased frequency of 2DS3 (p=0.018). Additionally, in cirrhotic patients we found an increased frequency of individuals having two copies of 3DS1 and HLA-Bw4 (p=0.016). We conclude that higher NK cytotoxicity might be associated with a worse progression of the HCV infection.