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Wwox seletion in mouse B cells leads to genomic instability, neoplastic transformation, and monoclonal gammopathies
(Frontiers Media S.A., 2019-06)
WWOX (WW domain containing oxidoreductase) expression loss is common in various cancers and characteristic of poor prognosis. Deletions, translocations, and loss of expression affecting the WWOX gene are a common feature ...
Genome sequence of Methanobacterium congolense strain Buetzberg, a hydrogenotrophic, methanogenic archaeon, isolated from a mesophilic industrial-scale biogas plant utilizing bio-waste
(Elsevier Science, 2017-04)
Methanogenic Archaea are of importance at the end of the anaerobic digestion (AD) chain for biomass conversion. They finally produce methane, the end-product of AD. Among this group of microorganisms, members of the genus ...
Comprehensive evolutionary analysis of complete Epstein Barr virus genomes from Argentina and other geographies
(Molecular Diversity Preservation International, 2021-06)
The sequence variability of the Epstein–Barr virus has been extensively studied throughout previous years in isolates from various geographic regions and consequent variations at both genetic and genomic levels have been ...
Enhancer turnover and conserved regulatory function in vertebrate evolution
(The Royal Society, 2013-12)
Mutations in regulatory regions including enhancers are an important source of variation and innovation during evolution. Enhancers can evolve by changes in the sequence, arrangement and repertoire of transcription factor ...
INSECT 2.0: A web-server for genome-wide cis-regulatory modules prediction
(Oxford University Press, 2016-04)
INSECT is a user-friendly web server to predict the occurrence of Cis-Regulatory Modules (CRMs), which control gene expression. Here, we present a new release of INSECT which includes several new features, such as whole ...
Overlapping local and long-range RNA-RNA interactions modulate dengue virus genome cyclization and replication
(American Society For Microbiology, 2015-03)
The dengue virus genome is a dynamic molecule that adopts different conformations in the infected cell. Here, using RNA folding predictions, chemical probing analysis, RNA binding assays, and functional studies, we identified ...
Macromolecular crowding links ribosomal protein gene dosage to growth rate in Vibrio cholerae
(BioMed Central, 2020-04)
In fast-growing bacteria, the genomic location of ribosomal protein (RP) genes is biased towards the replication origin (oriC). This trait allows optimizing their expression during exponential phase since oriC neighboring ...
Novel zebrafish mono-α2,8-sialyltransferase (ST8Sia VIII): An evolutionary perspective of α2,8-sialylation
(MDPI, 2019-01)
The mammalian mono-α2,8-sialyltransferase ST8Sia VI has been shown to catalyze the transfer of a unique sialic acid residues onto core 1 O-glycans leading to the formation of di-sialylated O-glycosylproteins and to a lesser ...
Genome editing in potato via CRISPR-Cas9 ribonucleoprotein delivery
(Wiley Blackwell Publishing, Inc, 2018-12)
Clustered regularly interspaced short palindromic repeats and CRISPR-associated protein-9 (CRISPR-Cas9) can be used as an efficient tool for genome editing in potato (Solanum tuberosum). From both a scientific and a ...
Comparative analysis of zygotic developmental genes in Rhodnius prolixus genome shows conserved features on the tracheal developmental pathway
(Pergamon-Elsevier Science Ltd, 2015-09)
Most of the in-depth studies on insect developmental genetic have been carried out in the fruit fly Drosophila melanogaster, an holometabolous insect, so much more still remains to be studied in hemimetabolous insects. ...