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A natural oil increases specific anti-OVA IgG levels and induces a cellular immune response combined with aluminum hydroxide
(Federation of American Societies for Experimental Biology, 2020-08)
The efficacy of certain vaccines is improved by the use of adjuvants. Nowadays, the development of new, effective, and safe adjuvants that stimulate the innate immune response is researched. In this context, medicinal ...
Airway structural cells regulate TLR5-mediated mucosal adjuvant activity
(Nature Publishing Group, 2014-05)
Antigen-presenting cell (APC) activation is enhanced by vaccine adjuvants. Most vaccines are based on the assumption that adjuvant activity of Toll-like receptor (TLR) agonists depends on direct, functional activation of ...
Immunization with Tc52 or its amino terminal domain adjuvanted with c-di-AMP induces Th17+Th1 specific immune responses and confers protection against Trypanosoma cruzi
(Public Library of Science, 2017-02)
The development of new adjuvants enables fine modulation of the elicited immune responses. Ideally, the use of one or more adjuvants should result in the induction of a protective immune response against the specific ...
Evaluation of lactobacillus probiotics as adjuvants for nasal immunization with chimeric pneumococcal vaccineИспользование лактобацилл в качестве адъювантов при интраназальной иммунизации химерной пневмококковой вакциной
(Russian Association of Allergologists and Clinical Immunologists, 2016-09)
Vaccine protection against photogenic gram-positive bacteria including different species of streptococci is an important problem of contemporary molecular biology. Streptococcal infections are most common bacterial infections ...
Class-B CpG-ODN formulated with a nanostructure induces type I interferons-dependent and CD4+T cell-independent CD8+T-Cell response against unconjugated protein antigen
(Frontiers Media S.A., 2018-10)
There is a need for new vaccine adjuvant strategies that offer both vigorous antibody and T-cell mediated protection to combat difficult intracellular pathogens and cancer. To this aim, we formulated class-B synthetic ...
Total Leishmania antigens with Poly(I:C) induce Th1 protective response
(Wiley Blackwell Publishing, Inc, 2017-11)
Our proposal was to develop a vaccine based on total Leishmania antigens (TLA) adjuvanted with polyinosinic-polycytidylic acid [Poly(I:C)] able to induce a Th1 response which can provide protection against Leishmania ...
Systemic administration of imiquimod as an adjuvant improves immunogenicity of a tumor-lysate vaccine inducing the rejection of a highly aggressive T-cell lymphoma
(Academic Press Inc Elsevier Science, 2019-06)
T-cell lymphomas include diverse malignancies. They are rare, some have low survival rates and they lack curative therapies. The aim of this work was to assess whether employing the TLR7 agonist imiquimod and the T-cell ...
Biosynthesis of emulsan biopolymers from agro-based feedstocks
(Wiley Blackwell Publishing, Inc, 2007-03-03)
Aims: The need for biocompatible, biodegradable, and versatile biopolymers permeates many fields including environmental and food technology. The goal of the study presented here is to establish the utility of agricultural ...
Efficient immune responses against Intimin and EspB of enterohaemorragic Escherichia coli after intranasal vaccination using the TLR2/6 agonist MALP-2 as adjuvant
(Elsevier, 2008-10)
Mucosal vaccine formulations based on purified recombinant C280 γ-Intimin and EspB (Escherichia coli secreted protein B) from enterohaemorragic E. coli co-administered with a pegylated derivative of the TLR2/6 agonist ...
Brucella abortus Omp19 recombinant protein subcutaneously co-delivered with an antigen enhances antigen-specific T helper 1 memory responses and induces protection against parasite challenge
(Elsevier, 2016-01)
The discovery of effective adjuvants for many vaccines especially those with limited commercial appeal, such as vaccines to poverty-related diseases, is required. In this work, we demonstrated that subcutaneous co-administration ...