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Otoferlin acts as a Ca2+ sensor for vesicle fusion and vesicle pool replenishment at auditory hair cell ribbon synapses
(eLife Sciences Publications, 2017-11-07)
Hearing relies on rapid, temporally precise, and sustained neurotransmitter release at the ribbon synapses of sensory cells, the inner hair cells (IHCs). This process requires otoferlin, a six C2-domain, Ca2+-binding ...
Differential Coupling of Adult-Born Granule Cells to Parvalbumin and Somatostatin Interneurons
(Elsevier Inc, 2020-01)
A strong GABAergic tone imposes sparse levels of activity in the dentate gyrus of the hippocampus. This balance is challenged by the addition of new granule cells (GCs) with high excitability. How developing GCs integrate ...
Growth hormone secretagogue receptor constitutive activity impairs voltage-gated calcium channel-dependent inhibitory neurotransmission in hippocampal neurons
(Wiley Blackwell Publishing, Inc, 2018-11)
Key points: Presynaptic CaV2 voltage-gated calcium channels link action potentials arriving at the presynaptic terminal to neurotransmitter release. Hence, their regulation is essential to fine tune brain circuitry. CaV2 ...
The energetic brain – A review from students to students
(Wiley Blackwell Publishing, Inc, 2019-10)
The past 20 years have resulted in unprecedented progress in understanding brain energy metabolism and its role in health and disease. In this review, which was initiated at the 14th International Society for Neurochemistry ...
Neuronal and synaptic morphological alterations in the hippocampus of cannabinoid receptor type 1 knockout mice
(Wiley-liss, div John Wiley & Sons Inc., 2020-07)
Cannabinoid receptor type 1 (CB1R) modulates synaptic activity and is widely distributed in brain areas such as the hippocampus, cerebellum, cerebral cortex, and striatum, among others. CB1R is involved in processes such ...
Are Glial Cells Critical Participants in Brain Development, Function, and Disease?
(OMINCS, 2012-09)
Recently, an increasing number of studies have implicated a third element in plasticity; the perisynaptic glial cell. Originally glial cells were thought to be important for metabolic maintenance and support of Central The ...
Editorial: Glial cells, maladaptive plasticity, and neurodegeneration: Mechanisms, targeted therapies, and future directions
(Frontiers Media S.A., 2021-04-30)
Understanding the biological complexity of the central nervous system (CNS) is a frontier in neuroscience. Morphological organization of the CNS represents the basis for its functional properties underlying higher brain ...
Synaptic NF-kappa B pathway in neuronal plasticity and memory
(Elsevier, 2014-05)
Several transcription factors are present at the synapse, and among these are the Rel-NF-kappa B pathway components. NF-kappa B is a constitutive transcription factor, with a strong presence in the brain of which a ...
Presynaptic Effects of N-Methyl-D-Aspartate Receptors Enhance Parvalbumin Cell–Mediated Inhibition of Pyramidal Cells in Mouse Prefrontal Cortex
(Elsevier Science Inc, 2018-09)
Background: Testing hypotheses regarding the role of N-methyl-D-aspartate receptor (NMDAR) hypofunction in schizophrenia requires understanding the mechanisms of NMDAR regulation of prefrontal cortex (PFC) circuit function. ...
Impact of sub- and supra- threshold switching in the synaptic behavior of TiO2 memristors
(Elsevier Science, 2018-06)
Al/TiO2/Au memory junctions grown by reactive sputtering were fabricated and characterized. Usual hysteretic features were obtained, spanning an order of magnitude ratio between high and low resistance states. We explored ...