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Cruzipain and Its Physiological Inhibitor, Chagasin, as a DNA-Based Therapeutic Vaccine Against Trypanosoma cruzi
(Frontiers Media S.A., 2020-10)
Chagas disease caused by the protozoan parasite Trypanosoma cruzi is endemic in 21 Latin American countries and the southern United States and now is spreading into several other countries due to migration. Despite the ...
Homologous prime-boost strategy with TgPI-1 improves the immune response and protects highly susceptible mice against chronic Toxoplasma gondii infection
(Elsevier Science, 2015-07)
Subunit-based vaccines are safer than live or attenuated pathogen vaccines, although they are generally weak immunogens. Thus, proper combination of immunization strategies and adjuvants are needed to increase their efficacy. ...
Immunization with Brucella VirB proteins elicits a protective Th1 immune response in mice and 1 a similar immune response in dogs
(American Society For Microbiology, 2015-03)
VirB proteins from Brucella spp. constitute the Type IV secretion system, a key virulence factor mediating the intracellular survival of these bacteria. Here we assessed whether a Th1-type immune response against VirB ...
Plataforma basada en proteínas de superficie de protozoarios para la generación de vacunas oralesPlatform for the generation of oral vaccines based on protozoan surface proteins
(Medicina (Buenos Aires), 2019-12)
La propagación internacional de enfermedades infecciosas constituye un problema global de seguridad sanitaria. La vacunación es una de las intervenciones en salud más exitosas y efectivas. La administración por vía oral ...
Elicitor-Based Biostimulant PSP1 Protects Soybean Against Late Season Diseases in Field Trials
(Frontiers Media SA, 2018-06-12)
Currently, fungicide application in soybean production accounts for an important amount of global pesticide use, and it is therefore most desirable to find new healthier and more environmental friendly alternatives for the ...
Oral vaccination with hepatitis E virus capsid protein and immunobiotic bacterium-like particles induce intestinal and systemic immunity in mice
(Springer, 2020-09)
Hepatitis E is the major enterically transmitted viral hepatitis after hepatitis A. There are four known genotypes (GT) of the hepatitis E virus (HEV) affecting human beings. HEV GT1 causes outbreaks of acute hepatitis in ...
Immunization with Neospora caninum profilin induces limited protection and a regulatory T-cell response in mice
(Academic Press Inc Elsevier Science, 2015-11)
Profilins are actin-binding proteins that regulate the polymerization of actin filaments. In apicomplexan parasites, they are essential for invasion. Profilins also trigger the immune response of the host by activating ...
RHBDD2 overexpression promotes a chemoresistant and invasive phenotype to rectal cancer tumors via modulating UPR and focal adhesion genes
(Elsevier Science, 2020-08)
The current standard of care for locally advanced rectal cancer (RC) is neoadjuvant radio-chemotherapy (NRC) with 5-fluorouracil (5Fu) as the main drug, followed by surgery and adjuvant chemotherapy. While a group of ...
Expansion of myeloid-derived suppressor cells with arginase activity lasts longer in aged than in young mice after CpG-ODN plus IFA treatment
(Impact Journals LLC, 2015-04)
As we age, the homeostatic function of many systems in the body, such as the immune function declines, which in turn contributes to augment susceptibility to disease. Here we describe that challenging aged mice with synthetic ...
Effect of free and nanoencapsulated copaiba oil on monocrotaline-induced pulmonary arterial hypertension
(Lippincott Williams, 2017-02)
Copaiba oil comes from an Amazonian tree and has been used as an alternative medicine in Brazil. However, it has not been investigated yet in the treatment of cardiovascular diseases. This study was designed to test whether ...