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Urban air pollution induces redox imbalance and epithelium hyperplasia in mice cornea
(Academic Press Inc Elsevier Science, 2019-12-01)
The aim of the study was to evaluate the time course of the effects of urban air pollutants on the ocular surface, focusing on the morphological changes, the redox balance, and the inflammatory response of the cornea. ...
Neutrophils from chronic lymphocytic leukemia patients exhibit an increased capacity to release extracellular traps (NETs)
(Springer, 2016-10-28)
Chronic lymphocytic leukemia (CLL) is characterized by immune defects that contribute to a high rate of infections and autoimmune cytopenias. Neutrophils are the first line of innate immunity and respond to pathogens through ...
Peroxiredoxin 6 regulates the phosphoinositide 3-kinase/AKT pathway to maintain human sperm viability
(Oxford University Press, 2019-10)
Peroxiredoxins (PRDXs) are antioxidant enzymes proven to control the levels of reactive oxygen species (ROS) and to avoid oxidative damage in the spermatozoon. Previously, we have shown that low amounts of PRDXs are ...
Nitro-oleic acid triggers ROS production via NADPH oxidase activation in plants: A pharmacological approach
(Elsevier Gmbh, 2020-03)
Nitrated fatty acids (NO2-FAs) are important signaling molecules in mammals. NO2-FAs are formed by the addition reaction of nitric oxide- and nitrite-derived nitrogen dioxide with unsaturated fatty acid double bonds. The ...
Cardiac changes in apoptosis, inflammation, oxidative stress, and nitric oxide system induced by prenatal and postnatal zinc deficiency in male and female rats
(Springer, 2016-11)
Purpose: Zinc restriction during fetal and postnatal development could program cardiovascular diseases in adulthood. The aim of this study was to determine the effects of zinc restriction during fetal life, lactation, ...
Tomato wall-associated kinase SlWak1 depends on Fls2/Fls3 to promote apoplastic immune responses to pseudomonas syringae
(American Society of Plant Biologist, 2020-08)
Wall-associated kinases (Waks) are important components of plant immunity against various pathogens, including the bacterium Pseudomonas syringae pv. tomato (Pst). However, the molecular mechanisms of their role(s) in plant ...
Ibuprofen, a traditional drug that may impact the course of COVID-19 new effective formulation in nebulizable solution
(Elsevier, 2020-11)
The traditional formulation of ibuprofen is poorly soluble in water, so the administered dose must be 10 times higher than the dose required for a therapeutic effect. The development of a hydrosoluble form of ibuprofen can ...
Estudio del polimorfismo del promotor del gen de la IL-6 en pacientes con sobrecarga de hierro primaria
(Revista de la Asociación Bioquímica Argentina, 2016-09)
La sobrecarga de hierro (SH) primaria ha sido vinculada a un estado proinflamatorio y a mayor riesgo de enfermedad cardiovascular (ECV). Entre los marcadores de inflamación asociados a ECV, se destacan la proteína C reactiva ...