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Combined therapy for alzheimer’s disease: Tacrine and PAMAM dendrimers co-administration reduces the side effects of the drug without modifying its activity
(Springer, 2020-03-25)
Alzheimer´s disease has become a public health priority, so an investigation of new therapies is required. Tacrine (TAC) was licensed for treatments; however, its oral administration caused hepatotoxicity, so it is essential ...
Bimodal therapeutic agents against Glioblastoma, one of the most lethal forms of cancer
(Wiley VCH Verlag, 2020-08)
About 95 % of people diagnosed with glioblastoma die within five years. Glioblastoma is the most aggressive central nervous system tumour. It is necessary to make progress in the glioblastoma treatment so that advanced ...
IGF1 gene therapy reversed cognitive deficits and restored hippocampal alterations after chronic spinal cord injury
(Springer Nature, 2021-12)
The hippocampus is implicated in the generation of memory and learning, processes which involve extensive neuroplasticity. The generation of hippocampal adult-born neurons is particularly regulated by glial cells of the ...
Suppression of cancer growth by non-viral gene therapy based on a novel reactive oxygen species-responsive promoter
(Cell Press, 2009-08)
Increased reactive oxygen species (ROS) production has been reported as a distinctive feature of different pathologies including cancer. Therefore, we assessed whether increased ROS production in the cancer microenvironment ...
Reactive oxygen species in cancer: A paradox between pro- and anti-tumour activities
(Springer, 2020-07)
Cancer constitutes a group of heterogeneous diseases that share common features. They involve the existence of altered cellular pathways which result in uncontrolled cell proliferation. Deregulation of production and/or ...
Neuroprotective role of hypothermia in hypoxic-ischemic brain injury: Combined therapies using estrogen
(Bentham Science Publishers, 2018-12)
Hypoxic-ischemic brain injury is a complex network of factors, which is mainly characterized by a decrease in levels of oxygen concentration and blood flow, which lead to an inefficient supply of nutrients to the brain. ...
Mechanistic studies of Candida albicans photodynamic inactivation with Porophyllum obscurum hexanic extract and its isolated thiophenic compounds
(Elsevier Science, 2019-06)
Porophyllum obscurum (Spreng) DC (Asteraceae) hexanic extract (PoHex) from aerial parts has demonstrated antifungal activity under UVA irradiation against Candida spp. isolates from patients with oropharyngeal candidiasis ...
Lentivector Transduction Improves Outcomes Over Transplantation of Human HSCs Alone in NOD/SCID/Fabry Mice
(Nature Publishing Group, 2012-07)
Fabry disease is a lysosomal storage disorder caused by a deficiency of a-galactosidase A (a-gal A) activity that results in progressive globotriaosylceramide (Gb(3)) deposition. We created a fully congenic nonobese diabetic ...
Isolation and initial characterization of human glioblastoma cells resistant to photodynamic therapy
(Elsevier Science, 2021-03)
Glioblastoma is the most severe form of brain cancer. Despite multimodal therapy combining surgery, radiotherapy and chemotherapy, prognosis of patients is dismal. It has been observed that the surgical resection guided ...
Growth hormone treatment in children with idiopathic short stature: correlation of growth response with peripheral thyroid hormone action
(Wiley Blackwell Publishing, Inc, 2011-03)
Idiopathic short stature (ISS) describes short children with normal GH secretion. Although GH treatment increases their heights, growth response to the therapy differs among patients. Thyroid hormones (TH) are essential ...