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Drug-based cancer therapy to overcome immune resistance by steering tumor evolution
(Informa Healthcare, 2019-01)
We argue that therapy must lead rather than follow vis-à-vis cancer evolution. Clinical experience suggests that the evading phenotype resulting from treatment can never be fully anticipated or eliminated when a single ...
Targeted radionuclide therapy: frontiers in theranostics
(Landmark, 2017-06-01)
The concept of targeted radionuclide therapy (TRT) relies on the use of injected nuclear medicine as treating agents, targeted at the cellular or molecular level. The growth of the interest in TRT was stimulated by the ...
Light and Shadows in cardiac regeneration.
(Sociedad Argentina de Fisiología, 2019-05)
Given that the adult human heart has an extremely limited regenerative capacity, diseases characterized by contractile cell loss, as myocardial infarction and cardiomyopathies, lead to ventricular remodeling and heart ...
Oxidative Stress in Muscle Diseases: Current and Future Therapy 2019
(Hindawi Publishing Corporation, 2020-04-22)
Increased oxidative stress has important molecular, structural, and functional muscle implications. In pathological conditions, reactive oxygen species (ROS) burst contributes to cellular dysfunction and the progression ...
Editorial: Modulating glial cells phenotype. New findings and therapies
(Frontiers Media, 2020-09-23)
Aging and neurodegenerative diseases are closely related, and the common point between both scenarios is neuroinflammation. Neuroinflammation is mainly mediated by glial cells, astrocytes, and microglia; while endothelial ...
Plants as source of new therapies for endometriosis: a review of preclinical and clinical studies
(Oxford University Press, 2020-10)
Given the disadvantages and limitations of current endometriosis therapy, there is a progressive increase in studies focusing on plant-derived agents as a natural treatment option with the intention of achieving high ...
Cytokine-enhanced vaccine and suicide gene therapy as adjuvant treatments of metastatic melanoma in a horse
(British Veterinary Association, 2009-02)
We evaluated the safety, efficacy and anti-tumour effects of a surgery adjuvant treatment on an equine patient with metastatic malignant melanoma. This approach combined suicide gene therapy with a subcutaneous vaccine ...
Disorders of sex development and hypogonadism: Genetics, mechanism, and therapies
(Hindawi Publishing Corporation, 2012-07)
Disorders of sex development (DSD) and hypogonadism are genetically heterogeneous and include a broad spectrum of phenotypes. Recent advances in biology and medicine have introduced impressive improvements in both clinical ...
What are the effects of swallowing therapy for people up to six months post stroke?
(Wiley, 2019-03)
Compared with usual care for people up to six months post stroke, swallowing therapy (acupuncture, behavioral intervention, drug therapy, neuromuscular or pharyngeal electrical stimulation, physical stimulation, transcranial ...
ErbB-2 nuclear function in breast cancer growth, metastasis and resistance to therapy
(BioScientifica, 2016-10)
Approximately 15-20% of breast cancers (BC) show either membrane overexpression of ErbB-2 (MErbB-2), a member of the ErbBs family of receptor tyrosine kinases, or ERBB2 gene amplification. Until the development of ...