info:eu-repo/semantics/article
Drug-based cancer therapy to overcome immune resistance by steering tumor evolution
Fecha
2019-01Registro en:
Fernandez, Ariel; Drug-based cancer therapy to overcome immune resistance by steering tumor evolution; Informa Healthcare; Expert Opinion On Drug Discovery; 14; 1; 1-2019; 5-8
1746-0441
CONICET Digital
CONICET
Autor
Fernandez, Ariel
Resumen
We argue that therapy must lead rather than follow vis-à-vis cancer evolution. Clinical experience suggests that the evading phenotype resulting from treatment can never be fully anticipated or eliminated when a single source of selection pressure is applied during treatment. Thus, therapy must steer cancer evolution and LIC may well become the underlying paradigm to overcome resistance in a therapeutic context where immune surveillance is maintained.