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Characterization of four Latin American families confirms previous findings and reveals novel features of acid-labile subunit deficiency
(Wiley, 2017)
Objective: Acid-labile subunit deficiency (ACLSD), caused by inactivating mutations in both IGFALS gene alleles, is characterized by marked reduction in IGF-I and IGFBP-3 levels associated with mild growth retardation. The ...
Acute exercise decreases PTP-1B protein level and improves insulin signaling in the liver of old rats
(2013-02-25)
It is now commonly accepted that chronic inflammation associated with obesity during aging induces insulin resistance in the liver. In the present study, we investigated whether the improvement in insulin sensitivity and ...
Actinobacillus actinomycetemcomitans lipopolysaccharide induces interleukin-6 expression through multiple mitogen-activated protein kinase pathways in periodontal ligament fibroblasts
(Blackwell Publishing, 2006-12-01)
Actinobacillus actinomycetemcomitans plays a major role in the pathogenesis of aggressive periodontitis. Lipopolysaccharide (LPS) derived from A. actinomycetemcomitans is a key factor in inflammatory cytokine generation ...
Laminin-binding epitope on gp43 from Paracoccidioides brasiliensis is recognized by a monoclonal antibody raised against Staphylococcus aureus laminin receptor
(1997-03-03)
Adhesion is regarded as an important step in the pathogenesis of several microorganisms. Thus, the ability to recognize extracellular matrix proteins, such as laminin or fibronectin, has been correlated with invasiveness. ...
Dermcidin exerts its oncogenic effects in breast cancer via modulation of ERBB signaling
(Biomed Central Ltd, 2015-02-19)
Background: We previously identified dermicidin (DCD), which encodes a growth and survival factor, as a gene amplified and overexpressed in a subset of breast tumors. Patients with DCD-positive breast cancer have worse ...
Mechanisms associated to impaired activity of cardiac P-type ATPases in endothelial nitric oxide synthase knockout mice
(Servicio Publicaciones Universidad Navarra, 2013-06-01)
The effect of long-lasting in vivo restriction of nitric oxide (NO) bioavailability on cardiac and renal P-type ATPases critical for intracellular ion homeostasis is controversial. Previous work has shown in eNOS knockout ...
Brown spider dermonecrotic toxin directly induces nephrotoxicity
(Elsevier B.V., 2006-02-15)
Brown spider (Loxosceles genus) venom can induce dermonecrotic lesions at the bite site and systemic manifestations including fever, vomiting, convulsions, disseminated intravascular coagulation, hemolytic anemia and acute ...
Testosterone represses ubiquitin ligases atrogin-1 and Murf-1 expression in an androgen-sensitive rat skeletal muscle in vivo
(Amer Physiological Soc, 2010-02-01)
Pires-Oliveira M, Maragno AL, Parreiras-E-Silva LT, Chiavegatti T, Gomes MD, Godinho RO. Testosterone represses ubiquitin ligases atrogin-1 and Murf-1 expression in an androgen-sensitive rat skeletal muscle in vivo. J Appl ...
Growth inhibitory activity of a novel lectin from Cliona varians against K562 human erythroleukemia cells
(Springer, 2009-05-01)
Purpose in this study, the antitumoral potential of a novel lectin (CvL) purified from the marine sponge Cliona varians was studied in different cancer cell lines.Methods CvL cytotoxicity was evaluated in mammalian tumor ...
Hypothalamic stearoyl-CoA desaturase-2 (SCD2) controls whole-body energy expenditure
(Springer Nature, 2021)