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Modulation of MAPK and NF-κB Signaling Pathways by Antioxidant Therapy in Skeletal Muscle of Heart Failure Rats
(2016-07-01)
Background/Aims: Although increased oxidative stress plays a role in heart failure (HF)-induced skeletal myopathy, signaling pathways involved in muscle changes and the role of antioxidant agents have been poorly addressed. ...
Mechanisms involved in p53 downregulation by leptin in trophoblastic cells
(W B Saunders Co Ltd, 2015-11)
Leptin, a 16-kDa polypeptide hormone, is produced by the adipocyte and can also be synthesized by placenta. We previously demonstrated that leptin promotes proliferation and survival in placenta, in part mediated by the ...
Selective modulation of the CAP/Cbl pathway in the adipose tissue of high fat diet treated rats
(Elsevier Science BvAmsterdamHolanda, 2006)
Dampening the signals transduced through hedgehog via microRNA miR-7 facilitates Notch-induced tumourigenesis
(Public Library Science, 2013-05-07)
Fine-tuned Notch and Hedgehog signaling pathways via attenuators and dampers have long been recognized as important<br />mechanisms to ensure the proper size and differentiation of many organs and tissues. This notion is ...
PI3K pathway is involved in ERK signaling cascade activation by histamine H2R agonist in HEK293T cells
(Elsevier Science, 2016-06-15)
Histamine, through histamine H2 receptor (H2R), modulates different biological processes, involving the modulation of PI3K/AKT/mTOR and RAS/RAF/MEK/ERK pathways. Many evidences have demonstrated the existence and importance ...
WNT signaling in neuronal maturation and synaptogenesis
(Frontiers, 2013-07)
The Wnt signaling pathway plays a role in the development of the central nervous system and growing evidence indicates that Wnts also regulates the structure and function of the adult nervous system. Wnt components are key ...
Understanding intellectual disability through RASopathies
(Elsevier, 2014-05)
Intellectual disability, commonly known as mental retardation in the International Classification of Disease from World Health Organization, is the term that describes an intellectual and adaptive cognitive disability that ...
Palmitate Activates Insulin Signaling Pathway in Pancreatic Rat Islets
(LIPPINCOTT WILLIAMS & WILKINS, 2009)
Objective: To investigate the action of palmitate on insulin receptor (IR) signaling pathway in rat pancreatic islets. The following proteins were studied: IR substrate-1 and -2 (IRS1 and IRS2), phosphatidylinositol 3-kinase, ...