Artículos de revistas
Selective modulation of the CAP/Cbl pathway in the adipose tissue of high fat diet treated rats
Registro en:
Febs Letters. Elsevier Science Bv, v. 580, n. 20, n. 4889, n. 4894, 2006.
0014-5793
WOS:000240371000021
10.1016/j.febslet.2006.08.004
Autor
Prada, PO
Pauli, JR
Ropelle, ER
Zecchin, HG
Carvalheira, JBC
Velloso, LA
Saad, MJA
Institución
Resumen
A high-fat diet (HFD) is associated with reduced glucose uptake in muscle, but not in adipose tissue. In the present study, we investigated whether a HFD can modulate glucose uptake in adipose tissue by increasing signal transduction through the CAP/Cbl pathway, independently of the PI3-K/Akt pathway. Our results suggest that, in HFD, the differential regulation of insulin-induced glucose uptake between skeletal muscle and adipose tissue may, in part, be a consequence of the CAP/Cbl/C3G pathway, since the expression of CAP and Cbl, and also the activation of this pathway were increased in adipose tissue but not in muscle. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. 580 20 4889 4894