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Distinct patterns of somatic alterations in a lymphoblastoid and a tumor genome derived from the same individual
(OXFORD UNIV PRESS, 2011)
Although patterns of somatic alterations have been reported for tumor genomes, little is known on how they compare with alterations present in non-tumor genomes. A comparison of the two would be crucial to better characterize ...
Validation of an NGS panel designed for detection of actionable mutations in tumors common in latin america
(MDPI, 2021)
Next-generation sequencing (NGS) is progressively being used in clinical practice. However, several barriers preclude using this technology for precision oncology in most Latin American countries. To overcome some of these ...
Somatic evolution and global expansion of an ancient transmissible cancer lineage
(2019-08-02)
The canine transmissible venereal tumor (CTVT) is a cancer lineage that arose several millennia ago and survives by “metastasizing” between hosts through cell transfer. The somatic mutations in this cancer record its ...
Germline Mutations in PALB2, BRCA1, and RAD51C, Which Regulate DNA Recombination Repair, in Patients With Gastric Cancer
(W B Saunders Co-Elsevier Inc, 2017-04)
Up to 10% of cases of gastric cancer are familial, but so far, only mutations in CDH1 have been associated with gastric cancer risk. To identify genetic variants that affect risk for gastric cancer, we collected blood ...
A thermodynamic limit constrains complexity and primitive social function
(Cambridge Univ Press, 2019-08-01)
The evolutionary trend toward increasing complexity and social function is ultimately the result of natural selection's paradoxical tendency to foster cooperation through competition. Cooperating populations ranging from ...
MuPeXI: prediction of neo-epitopes from tumor sequencing data
(Springer, 2017-09)
Personalization of immunotherapies such as cancer vaccines and adoptive T cell therapy depends on identification of patient-specific neo-epitopes that can be specifically targeted. MuPeXI, the mutant peptide extractor and ...
Clinical and molecular aspects of a pediatric metachronous adrenocortical tumor
(Sociedade Brasileira de Endocrinologia e Metabologia, 2011)
The occurrence of metachronous adrenocortical carcinoma has rarely been described. We report a case of a child with virilizing adrenocortical metachronous tumors that, despite several metastases, presented long-term survival ...
Somatic cytogenetic and azoospermia factor gene microdeletion studies in infertile men
(Associação Brasileira de Divulgação Científica, 2006)
Lack of mutations of exon 2 of the MEN1 gene in endocrine and nonendocrine sporadic tumors
(Associação Brasileira de Divulgação Científica, 2001)