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Experimental validation of the predictions of a mathematical model for protein purification and tag selection
(2010)
To improve downstream processing, protein engineering can be used to modify particular properties of a protein, such as specific affinity, charge, or hydrophobicity. The most common modification involves the peptide tags ...
Molecular assay optimized by Taguchi experimental design method for venous thromboembolism investigation
(Academic Press Ltd Elsevier B.V. Ltd, 2011-10-01)
Two mutations - Factor V Leiden (1691G > A) and the 20210G > A on the Prothrombin gene - are key risk factors for a frequent and potentially fatal disorder called Venous Thromboembolism. These molecular alterations can be ...
Outcomes of adrenal-sparing surgery or total adrenalectomy in phaeochromocytoma associated with multiple endocrine neoplasia type 2: an international retrospective population-based study
(Elsevier Science Inc, 2014-05)
Background
The prevention of medullary thyroid cancer in patients with multiple endocrine neoplasia type 2 syndrome has demonstrated the ability of molecular diagnosis and prophylactic surgery to improve patient outcomes. ...
Disruption of the 2-methylcitric acid cycle and evaluation of poly-3-hydroxybutyrate-co-3-hydroxyvalerate biosynthesis suggest alternate catabolic pathways of propionate in Burkholderia sacchari
(NATL RESEARCH COUNCIL CANADA-N R C RESEARCH PRESS, 2009)
The objective of the present work was to evaluate the relevance of the 2-methylcitric acid cycle (2MCC) to the catabolism of propionate in Burkholderia sacchari. Two B. sacchari mutants unable to grow on propionate were ...
De la construcción de la memoria a la identidad como mutación: apuntes sobre España de Manuel Vilas
(Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación. Centro de Teoría y Crítica Literaria, 2014-12)
Este trabajo analiza los procedimientos narrativos de España de Manuel Vilas en torno de la construcción de la identidad nacional. Esta se constituye como un núcleo ‘pre-significativo’ al que los textos buscan referirse a ...
Low genetic diversities of rabies virus populations within different hosts in Brazil
(ELSEVIER SCIENCE BV, 2010)
The low rates of nonsynonymous evolution observed in natural rabies virus (RABV) isolates are suggested to have arisen in association with the structural and functional constraints operating on the virus protein and the ...
Occupational exposure to anesthetics leads to genomic instability, cytotoxicity and proliferative changes
(2016-09-01)
Data on the genotoxic and mutagenic effects of occupational exposure to the most frequently used volatile anesthetics are limited and controversial. The current study is the first to evaluate genomic instability, cell death ...
Algoritmo genético de agrupamento para formação de módulos de arranjo físico
(Universidade Federal de São Carlos, 2008)
O projeto de arranjo físico modular tem como base o agrupamento de máquinas em módulos a partir de subseqüências de operações comuns a um conjunto de peças. No método proposto por Huang (2003), os módulos de arranjo físico ...
Cold resistance in plants: A mystery unresolved
(Pontificia Universidad Católica de Valparaíso, 2009)