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Mostrando ítems 21-30 de 2058
A multilayer network approach for guiding drug repositioning in neglected diseases
(Public Library of Science, 2016-01)
Drug development for neglected diseases has been historically hampered due to lack of market incentives. The advent of public domain resources containing chemical information from high throughput screenings is changing the ...
Synthesis and evaluation of the antileishmanial activity of silver compounds containing imidazolidine-2-thione
(2019-05-01)
Abstract: A new series of silver compounds could be of interest on designing new drugs for the treatment of leishmaniasis. The compounds [Ag(phen)(imzt)]NO3(1), [Ag(phen)(imzt)]CF3SO3(2), [Ag(phen)2](BF4)·H2O (3), ...
Hybrid compounds as anti-infective agents
(Bentham Science Publishers, 2017-04)
Hybrid drugs are multi-target chimeric chemicals combining two or more drugs or pharmacophores covalently linked in a single molecule. In the field of anti-infective agents, they have been proposed as a possible solution ...
Assessment of the quality of simvastatin capsules from compounding pharmacies
(Revista De Saude PublicaSao PauloBrasil, 2010)
Amphibian secretions for drug discovery studies: A search for new antiparasitic and antifungal compounds
(2007-01-10)
The antiparasitic and antifungal activities of nine amphibian skin secretions were studied in different in vitro models. Seven secretions presented a considerable antiprotozoan activity and one showed promising results ...
Yeast Double Transporter Gene Deletion Library for Identification of Xenobiotic Carriers in Low or High Throughput
(Amer Soc Microbiology, 2021-11-01)
The routes of uptake and efflux should be considered when developing new drugs so that they can effectively address their intracellular targets. As a general rule, drugs appear to enter cells via protein carriers that ...