Artículos de revistas
In Vitro Studies On The Release Of Isoniazid Incorporated In Poly(epsilon-caprolactone).
Journal Of Chemotherapy (florence, Italy). v. 18, n. 5, p. 473-9, 2006-Oct.
De Oliveira, A F
De Azevedo, M M M
A polymeric micro- and nanosphere formulation using poly (epsilon-caprolactone) (PCL) to entrap an antituberculosis drug, isoniazid (INH), was developed and characterized. The microspheres were prepared by a solvent evaporation method using ethyl acetate, PCL and INH as the organic phase and water and Tween 40 as the aqueous phase. The nanospheres were prepared by a spontaneous emulsification solvent diffusion method using 40% ethanol in acetone (v/v), PCL and INH as the organic phase and water and Tween 40 as the aqueous phase. After freeze-drying, these systems were characterized by scanning electron microscopy (SEM), particle size analysis, determination of entrapped INH content, in vitro INH release and brine shrimp toxicity bioassay.18473-9