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Combined docosahexaenoic acid and thyroid hormone supplementation as a protocol supporting energy supply to precondition and afford protection against metabolic stress situations
(Blackwell Publishing Ltd, 2019)
Liver preconditioning (PC) refers to the development of an enhanced tolerance to injuring stimuli. For example, the protection from ischemia–reperfusion (IR) in the liver that is obtained by previous maneuvers triggering ...
The effectiveness of antioxidant vitamins C and E in reducing myocardial infarct size in patients subjected to percutaneous coronary angioplasty (PREVEC Trial): study protocol for a pilot randomized double-blind controlled trial
(BioMed Central, 2014)
Background: Acute myocardial infarction (AMI) is the leading cause of mortality worldwide. Oxidative stress has
been involved in the ischemia-reperfusion injury in AMI. It has been suggested that reperfusion accounts for ...
Protection of the myocardium against ischemia/reperfusion injury by angiotensin-(1–9) through an AT2R and Akt-dependent mechanism
(Academic Press, 2018)
© 2018 Elsevier Ltd Angiotensin-(19), a peptide of the non-classical renin angiotensin system, has been shown to prevent and revert hypertension and cardiac hypertrophy. We hypothetized that systemic delivery of angiotensin-(1–9) ...
Down syndrome critical region 1 gene, Rcan1, helps maintain a more fused Mitochondrial Network
(Lippincott Williams & Wilkins, 2018)
Rationale: The regulator of calcineurin 1 (RCAN1) inhibits CN (calcineurin), a Ca2+-activated protein phosphatase important in cardiac remodeling. In humans, RCAN1 is located on chromosome 21 in proximity to the Down ...
Amelioration of persistent left ventricular function impairment through increased plasma ascorbate levels following myocardial infarction
(Taylor & Francis, 2016)
Purpose: Percutaneous coronary angioplasty (PCA) has been demonstrated to reduce mortality and morbidity and thereby improve the prognosis of patients undergoing acute myocardial infarctions (AMIs). However, this procedure ...
Kupffer-cell activity is essential for thyroid hormone rat liver preconditioning
(2010)
We studied the role of Kupffer cell functioning in T3 liver preconditioning against ischemia–reperfusion
(IR) injury using the macrophage inactivator gadolinium chloride (GdCl3) previous to T3 treatment. Male
Sprague–Dawley ...
Liver protective effects of extra virgin olive oil: interaction between Its chemical composition and the cell-signaling pathways involved in protection
(Bentham Science Publ LTD, 2018)
Background and Objective: The liver is an organ susceptible to a multitude of injuries that causes liver damage, like steatosis, non-alcoholic steatohepatitis, cirrhosis, hepatocellular carcinoma, and ischemia-reperfusion ...
Cytoprotective and suicidal signaling in oxidative stress
(Society of Biology of Chile, 2010)
Oxidative stress is an imbalance between pro-oxidants and antioxidants in favor of the pro-oxidants, leading to different responses depending on the level of pro-oxidants achieved and the duration of exposure. In this ...
Targeting kupffer cells with antisense oligonucleotides
(Frontiers in Bioscience, 2002)
© 2002 Frontiers in Bioscience. All rights reserved.During proinflammatory reactions such as endotoxemia, ischemia-reperfusion and immune reactions, excessive amounts of cytokines and prostanoids are released resulting in ...
Preconditioning tachycardia decreases the activity of the mitochondrial permeability transition pore in the dog heart
(2011)
Cardioprotection by preconditioning is a central issue of current research on heart function. Several reports indicate that preventing the assembly and opening of the mitochondrial permeability transition pore (mPTP) ...