Artículo de revista
Cytoprotective and suicidal signaling in oxidative stress
Fecha
2010Registro en:
Biol Res 43: 363-369, 2010
07176287
07169760
10.4067/S0716-97602010000300014
Autor
Videla Cabrera, Luis
Institución
Resumen
Oxidative stress is an imbalance between pro-oxidants and antioxidants in favor of the pro-oxidants, leading to different responses depending on the level of pro-oxidants achieved and the duration of exposure. In this article, we discuss the cytoprotective or suicidal signaling mechanisms associated with oxidative stress by addressing: (I) the development of an acute and mild pro-oxidant state by thyroid hormone administration eliciting the redox upregulation of the expression of proteins affording cell protection as a preconditioning strategy against ischemia-reperfusion liver injury; and (II) the role of prolonged and severe oxidative stress and insulin resistance as determinant factors in the pathogenesis of non-alcoholic fatty liver disease associated with obesity.