Morocco is a water-scarce developing country with a growing marketable agro-food industry, where untreated or insufficiently treated wastewater represents less than 1% of the irrigation water and treated wastewater reuse is virtually nil. The Government of Morocco is planning to increase the volume of treated wastewater reuse for irrigation agriculture under the current permissive regulation to alleviate the pressure on conventional water sources. However, the reuse of insufficiently treated wastewater implies environmental and human health risks besides the degradation of land and renewable natural resources. This paper shows the feasibility of increasing wastewater reuse for irrigation agriculture in Morocco and how the existing permissive regulation must be improved to force more efficient technologies aimed at ensuring the export of agricultural goods to the most restrictive international markets. The results show how the quality standards of Moroccan regulation are below that of their equivalents in developed countries, as well as in most of the consulted developing countries. After verifying that tertiary treatment is financially feasible, the updated regulation must also consider climatic water scarcity and the locally low cultural perception of environmental and human health risks in order to design optimal solutions. © 2022 by the authors.