This systematic review sought to investigate the influence of physical activity and physical fitness on cognitive functions and academic performance. Studies were identified in four databases from January 2010 through January 2021. A total of 26 studies were selected after meeting the established criteria. Nine studies showed an association between physical activity and physical fitness variables and academic performance. Cardiorespiratory fitness, speed-agility, motor coordination, and perceptual-motor skill had the strongest association with executive function, including attention, memory, inhibition and shifting in 17 studies. High levels of physical activity and physical fitness are associated with higher academic performance and executive function. More hours of Physical Education are needed to more effectively develop the cognitive aspects and physical fitness of children in elementary school. © 2022, Universidad Catolica San Antonio Murcia. All rights reserved.