artículo
C(-106)T polymorphism of the aldose reductase gene and the progression rate of diabetic retinopathy
Fecha
2006Registro en:
10.1016/j.diabres.2006.03.019
0168-8227
MEDLINE:16701918
WOS:000241649700010
Autor
Olmos, Pablo
Bastias, Maria Juliana
Vollrath, Valeska
Toro, Luis
Trincado, Arturo
Salinas, Pablo
Claro, Juan Carlos
Lopez, Jose Manuel
Acosta, Ana Maria
Miquel, Juan Francisco
Castro, Juan
Institución
Resumen
Purpose: To study the C(-106)T polymorphism in the promoter of the aldose reductase (ALR2) gene: (a) its local prevalence and (b) its modulation of the susceptibility for developing retinopathy. Methods: DNAs of 96 control subjects and 53 long-standing (duration 17.9 +/- 5.4 years) type-2 diabetic patients were analyzed by PCR-RFLP with BfaI enzyme. Retinopathy was graded with 2-eye, 7-field fundus color photography. The IMF-HbA1c was the arithmetic mean of all HbA1c's of each patient. Results: The genotypes in the controls were CC = 57 (59.4%), CT = 32 (33.3%) and TT = 7 (7.3%), with Hardy-Weinberg chi(2) = 0.793 (p > 0.50). Among 53 diabetics, CC = 24 (45.3%), CT = 26 (49.0%) and TT = 3 (5.7%). The correlation between IMF-HbA1c and retinopathy progression rate was significant on CC (r = 0.6102, p = 0.0072) but not in CT + TT genotypes (r = 0.26, p = 0.1811). Conclusions: In Chilean adults, the frequency of the C(-106)T polymorphism of the ALR2 gene was similar to that reported by others. Type-2 diabetics with the CC genotype were more susceptible for developing retinopathy as a result of chronic hyperglycemia than those with the CT or TT genotype. (c) 2006 Elsevier Ireland Ltd. All rights reserved.