artículo
Increased soluble markers of endothelial dysfunction in HIV-positive patients under highly active antiretroviral therapy
Fecha
2003Registro en:
10.1097/01.aids.0000050875.71999.ca
1473-5571
0269-9370
MEDLINE:12646805
WOS:000182566700020
Autor
Donati, KD
Rabagliati, R
Tumbarello, M
Tacconelli, E
Amore, C
Cauda, R
Lacoviello, L
Institución
Resumen
Higher levels of soluble adhesion molecules have been found before the introduction of highly active antiretroviral therapy (HAART) in HIV-positive compared with HIV-negative patients. To evaluate the impact of HAART on endothelial function we measured the plasmatic concentrations of soluble adhesion molecules in 120 HIV-positive patients. Concentrations of P-selectin and fibrinolytic factors were significantly higher in HAART patients, whereas soluble intercellular adhesion molecule-1 did not differ significantly. HAART may induce an activation of endothelial function both directly and indirectly through lipid alterations.