artículo
Short-term complications and post-acute sequelae in hospitalized paediatric patients with COVID-19 and obesity: A multicenter cohort study
Fecha
2022Registro en:
10.1111/ijpo.12980
978-3-030-28856-3
2047-76310
978-3-030-28855-6
20476310 20476302
36222077
SCOPUS_ID:85140058619
WOS:000817622900001
Autor
Valenzuela G.
Alarcon-Andrade G.
Schulze-Schiapacasse C.
Garcia-Salum T.
Pardo-Roa C.
Levican J.
Serrano E.
Avendano M.J.
Almonacid L.I.
Poblete-Cardenas E.
Salinas E.
Munoz-Marcos A.
Medina R.A.
Rodriguez R.
Manzur D.
Barriga J.
Gutierrez M.
Godoy L.
Aravena J.
Nicolaides I.
Martinez E.
Gomez-Canobbio C.
Jofre M.
Salinas A.
Loza C.
Munoz A.
Barja S.
Cespedes P.
Bermudez S.
Depaoli D.
Ormazabal N.
Institución
Resumen
© 2022 World Obesity Federation.Background: Obesity increases the severity of coronavirus disease 2019 illness in adults. The role of obesity in short-term complications and post-acute sequelae in children is not well defined. Objective: To evaluate the relationship between obesity and short-term complications and post-acute sequelae of SARS-CoV-2 infection in hospitalized paediatric patients. Methods: An observational study was conducted in three tertiary hospitals, including paediatric hospitalized patients with a confirmatory SARS-CoV-2 RT-PCR from March 2020 to December 2021. Obesity was defined according to WHO 2006 (0–2 years) and CDC 2000 (2–20 years) growth references. Short-term outcomes were intensive care unit admission, ventilatory support, superinfections, acute kidney injury, and mortality. Neurological, respiratory, and cardiological symptoms and/or delayed or long-term complications beyond 4 weeks from the onset of symptoms were considered as post-acute sequalae. Adjusted linear, logistic regression and generalized estimating equations models were performed. Results: A total of 216 individuals were included, and 67 (31.02%) of them had obesity. Obesity was associated with intensive care unit admission (aOR = 5.63, CI95% 2.90–10.94), oxygen requirement (aOR = 2.77, CI95% 1.36–5.63), non-invasive ventilatory support (aOR = 6.81, CI95% 2.11–22.04), overall superinfections (aOR = 3.02 CI95% 1.45–6.31), and suspected bacterial pneumonia (aOR = 3.00 CI95% 1.44–6.23). For post-acute sequalae, obesity was associated with dyspnea (aOR = 9.91 CI95% 1.92–51.10) and muscle weakness (aOR = 20.04 CI95% 2.50–160.65). Conclusions: In paediatric hospitalized patients with COVID-19, severe short-term outcomes and post-acute sequelae are associated with obesity. Recognizing obesity as a key comorbidity is essential to develop targeted strategies for prevention of COVID-19 complications in children.