Artículo
Estrogen signaling as a bridge between the nucleus and mitochondria in cardiovascular diseases
Fecha
2022-09Registro en:
Frontiers in Cell and Developmental Biology. Volume 10. 14 September 2022. Article number 968373
2296-634X
10.3389/fcell.2022.968373
Autor
Guajardo-Correa, Emanuel
Silva-Agüero, Juan Francisco
Calle, Ximena
Chiong, Mario
Henríquez, Mauricio
García-Rivas, Gerardo
Latorre, Mauricio
Parra, Valentina
Institución
Resumen
Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality
worldwide. Epidemiological studies indicate that pre-menopausal women are
more protected against the development of CVDs compared to men of the
same age. This effect is attributed to the action/effects of sex steroid hormones
on the cardiovascular system. In this context, estrogen modulates
cardiovascular function in physiological and pathological conditions, being
one of the main physiological cardioprotective agents. Here we describe the
common pathways and mechanisms by which estrogens modulate the
retrograde and anterograde communication between the nucleus and
mitochondria, highlighting the role of genomic and non-genomic pathways
mediated by estrogen receptors. Additionally, we discuss the presumable role
of bromodomain-containing protein 4 (BRD4) in enhancing mitochondrial
biogenesis and function in different CVD models and how this protein could
act as a master regulator of estrogen protective activity. Altogether, this review
focuses on estrogenic control in gene expression and molecular pathways, how
this activity governs nucleus-mitochondria communication, and its projection
for a future generation of strategies in CVDs treatment.