Artículo de revista
Effect of temperature in bursting of thalamic reticular cells
Efecto de la temperature en las descargas en ráfaga de la células del núcleo reticular del tálamo
Registration in:
0120-5552
Corporación Universidad de la Costa
REDICUC - Repositorio CUC
Author
Hernandez Bustos, Oscar Emilio
E. Zurek, Eduardo
Vera Mellao, David
Cepeda Emiliani, Alfonso
Institutions
Abstract
Objective: To show the relation between the four parameters associated to bursting discharges
of the thalamic reticular cells (TRNn): the maximum firing frequency (fmax) and the temperature
at which it occurs (Tfmax), the range of temperatures defined as the full width at half maximum
(∆Th
) and the maximum specific low threshold calcium conductance (GT).
Materials and Methods: In order to simulate the TRNn bursting activity, a computational
simulation model was implemented using the NEURON software, which incorporates morphological
and electrophysiological data, and stimuli properties closely related to reality.
Results: It was found that there are nonlinear relations between the parameters. The fmax
frequency follows a quadratic growth with temperature and tends asymptotically towards a
limit value with the maximum calcium conductance. In the same manner, ∆Th increases until
reaching a limit value as function of fmax and GT
. However, the increment per frequency unit is
bigger than the increment per conductance unit.
Conclusions: Four equations were obtained that model the relations between the parameters
associated to bursting discharges of the TRNn in rats and other neurons with similar characteristics
in different animal species.