Pre-Publicación
Guarana supplementation attenuated obesity, insulin resistance, and adipokines dysregulation induced by a standardized human Western diet via brown adipose tissue activation
Registro en:
Corporación Universidad de la Costa
REDICUC - Repositorio CUC
Autor
Calixto Bortolin, Rafael
Rodrigues Vargas, Amanda
de Miranda Ramos, Vitor
Gasparotto, Juciano
Rodrigues Chaves, Paloma
Schnorr, Carlos Eduardo
da Boit Martinello, Katia
Kleber Silveira, Alexandre
Mautone Gomes, Henrique
Kelly Rabelo, Thallita
Sartori Grunwald, Marcelo
Ligabue‐Braun, Rodrigo
Pens Gelain, Daniel
Fonseca Moreira, José Claudio
Institución
Resumen
Obesity is a metabolic disorder associated with adverse health consequences that has
increased worldwide at an epidemic rate. This has encouraged many people to utilize
nonprescription herbal supplements for weight loss without knowledge of their safety
or efficacy. However, mounting evidence has shown that some herbal supplements
used for weight loss are associated with adverse effects. Guarana seed powder is a
popular nonprescription dietary herb supplement marketed for weight loss, but no
study has demonstrated its efficacy or safety when administered alone. Wistar rats
were fed four different diets (low‐fat diet and Western diet with or without guarana
supplementation) for 18 weeks. Metabolic parameters, gut microbiota changes, and
toxicity were then characterized. Guarana seed powder supplementation prevented
weight gain, insulin resistance, and adipokine dysregulation induced by Western diet
compared with the control diet. Guarana induced brown adipose tissue expansion,
mitochondrial biogenesis, uncoupling protein‐1 overexpression, AMPK activation,
and minor changes in gut microbiota. Molecular docking suggested a direct activation
of AMPK by four guarana compounds tested here. We propose that brown adipose tissue activation is one of the action mechanisms involved in guarana supplementation‐
induced weight loss and that direct AMPK activation may underlie this mechanism.
In summary, guarana is an attractive potential therapeutic agent to treat obesity.