Artigo
α-Linolenic fatty acid supplementation decreases tumor growth and cachexia parameters in walker 256 tumor-bearing rats
Registro en:
SCHIESSEL, D. L. et al. α-Linolenic fatty acid supplementation decreases tumor growth and cachexia parameters in walker 256 tumor-bearing rats. Nutrition and Cancer, [S.l.], v. 67, n. 5, 2015.
Autor
Schiessel, Dalton Luiz
Yamazaki, Ricardo K.
Kryczyk, Marcelo
Coelho, Isabela
Yamaguchi, Adriana A.
Pequito, Daniele C. T.
Brito, Gleisson A. P.
Borghetti, Gina
Fernandes, Luiz C.
Institución
Resumen
Fish oil (FO) has been shown to affect cancer cachexia, tumor mass, and immunity cell. n-3 PUFA, specifically α-linolenic fatty acid (ALA), has controversial effects. We investigated this in nontumor-bearing Wistar rats fed regular chow (C), fed regular chow and supplemented with FO or Oro Inca oil (OI), and Walker 256 tumor-bearing rats fed regular chow (W), fed regular chow and supplemented with FO (WFO) or OI (WOI). Rats were supplemented (1g/kg body weight/day) during 4 wk and then the groups tumor-bearing were inoculated with Walker 256 tumor cells suspension and 14 days later the animals were killed. WFO increased EPA fivefold and DHA 1.5-fold in the tumor tissue compared to W (P < 0.05). OI supplementation increased of threefold of ALA when compared to W (P < 0.05). Tumor mass in WFO and OI was of 2.3-fold lower, as well as tumor cell proliferation of 3.0-fold tumor tissue lipoperoxidation increased of 76.6% and cox-2 expression was 20% lower. Cachexia parameters were attenuate, blood glucose (25% higher), Triacylglycerolemia (50% lower), and plasma TNF-α (65% lower; P < 0.05) and IL-6 (62.5% lower). OI, rich in ALA, caused the same effect on cancer as those seen in FO.