| dc.creator | Schiessel, Dalton Luiz | |
| dc.creator | Yamazaki, Ricardo K. | |
| dc.creator | Kryczyk, Marcelo | |
| dc.creator | Coelho, Isabela | |
| dc.creator | Yamaguchi, Adriana A. | |
| dc.creator | Pequito, Daniele C. T. | |
| dc.creator | Brito, Gleisson A. P. | |
| dc.creator | Borghetti, Gina | |
| dc.creator | Fernandes, Luiz C. | |
| dc.date | 2019-11-14T12:25:04Z | |
| dc.date | 2019-11-14T12:25:04Z | |
| dc.date | 2015 | |
| dc.date.accessioned | 2023-09-28T19:57:57Z | |
| dc.date.available | 2023-09-28T19:57:57Z | |
| dc.identifier | SCHIESSEL, D. L. et al. α-Linolenic fatty acid supplementation decreases tumor growth and cachexia parameters in walker 256 tumor-bearing rats. Nutrition and Cancer, [S.l.], v. 67, n. 5, 2015. | |
| dc.identifier | http://repositorio.ufla.br/jspui/handle/1/37625 | |
| dc.identifier | https://www.tandfonline.com/doi/abs/10.1080/01635581.2015.1043021 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/9041242 | |
| dc.description | Fish oil (FO) has been shown to affect cancer cachexia, tumor mass, and immunity cell. n-3 PUFA, specifically α-linolenic fatty acid (ALA), has controversial effects. We investigated this in nontumor-bearing Wistar rats fed regular chow (C), fed regular chow and supplemented with FO or Oro Inca oil (OI), and Walker 256 tumor-bearing rats fed regular chow (W), fed regular chow and supplemented with FO (WFO) or OI (WOI). Rats were supplemented (1g/kg body weight/day) during 4 wk and then the groups tumor-bearing were inoculated with Walker 256 tumor cells suspension and 14 days later the animals were killed. WFO increased EPA fivefold and DHA 1.5-fold in the tumor tissue compared to W (P < 0.05). OI supplementation increased of threefold of ALA when compared to W (P < 0.05). Tumor mass in WFO and OI was of 2.3-fold lower, as well as tumor cell proliferation of 3.0-fold tumor tissue lipoperoxidation increased of 76.6% and cox-2 expression was 20% lower. Cachexia parameters were attenuate, blood glucose (25% higher), Triacylglycerolemia (50% lower), and plasma TNF-α (65% lower; P < 0.05) and IL-6 (62.5% lower). OI, rich in ALA, caused the same effect on cancer as those seen in FO. | |
| dc.language | en_US | |
| dc.publisher | Taylor & Francis Online | |
| dc.rights | restrictAccess | |
| dc.source | Nutrition and Cancer | |
| dc.title | α-Linolenic fatty acid supplementation decreases tumor growth and cachexia parameters in walker 256 tumor-bearing rats | |
| dc.type | Artigo | |
