Otro
Enhanced nicotine-seeking behavior following pre-exposure to repeated cocaine is accompanied by changes in BDNF in the nucleus accumbens of rats
Registro en:
Pharmacology Biochemistry and Behavior, v. 104, n. 1, p. 169-176, 2013.
0091-3057
1873-5177
10.1016/j.pbb.2013.01.007
WOS:000316594400022
2-s2.0-84874155130.pdf
2-s2.0-84874155130
Autor
Leão, Rodrigo M.
Cruz, Fábio C.
Carneiro-De-Oliveira, Paulo E.
Rossetto, Daniella B.
Valentini, Sandro Roberto
Zanelli, Cleslei Fernando
Planeta, Cleopatra da Silva
Resumen
We investigated the behavioral and molecular interactions between cocaine and nicotine, through evaluating locomotor activity, nicotine intravenous self-administration and gene expression. Locomotor sensitization was induced in male Wistar rats by repeated cocaine (20 mg/kg; i.p.) or saline injections once a day over 7 days. Three days after the last injection, rats were challenged with either saline or cocaine (15 mg/kg; i.p.) and the locomotor activity was measured. The very next day animals received either saline or nicotine (0.4 mg/kg; s.c.) and the locomotor cross-sensitization was tested. Animals were then prepared with intrajugular catheters for nicotine self-administration. Nicotine self-administration patterns were evaluated using fixed or progressive ratio schedules of reinforcement and a 24-h unlimited access binge. Immediately after the binge sessions animals were decapitated, the brains were removed and the nucleus accumbens was dissected. The dynorphin (DYN), μ-opioid receptor (mu opioid), neuropeptide Y (NPY), brain-derived neurotrophic factor (BDNF), tropomyosin-related tyrosine kinase B receptor (TrkB) and corticotropin- releasing factor receptor type 1 (CRF-R1) gene expression were measured by the reverse transcription-polymerase chain reaction (RT-PCR). Pretreatment with cocaine caused sensitization of cocaine motor response and locomotor cross-sensitization with nicotine. In the self-administration experiments repeated cocaine administration caused an increase in the nicotine break point and nicotine intake during a 24 h binge session. © 2013 Elsevier Inc.
Materias
Ítems relacionados
Mostrando ítems relacionados por Título, autor o materia.
-
Interacciones entre factores de crecimiento (GFs) y el receptor de progesterona (PR) en cáncer de mama.
Elizalde, Patricia Virginia; Proietti Anastasi, Cecilia Jazmín; Schillaci, Roxana; Balaña, Maria Eugenia; Labriola, Leticia; Salatino, Mariana; Beguelin, Wendy; Carnevale, Romina Paula; Díaz Flaqué, María Celeste; Charreau, Eduardo Hernan (Federación Bioquímica de la Provincia Buenos Aires, 2011-12)En trabajos previos hemos demostramos la existencia de interacciones bi-direccionales entre las vías de los progestá- genos y de la heregulina (HRG) en cáncer mamario. Encontramos que los progestágenos regulan la actividad ... -
Expressão do fator de crescimento endotelial vascular (VEGF) e seus receptores Flt-1 e Flk-1 após envenenamento pela aranha Phoneutria nigriventer em ratos = Expression of vascular endothelial growth factor (VEGF) and its receptors Flt-1 and Flk-1 after envenoming by Phoneutria nigriventer spider in rats
Mendonça, Monique Culturato Padilha, 1986-