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Social defeat stress in rats: escalation of cocaine and speedball binge self-administration, but not heroin
(Springer, 2011-05-01)
Exposure to intermittent episodes of social defeat stress can increase drug seeking and leads to intense drug taking in rats.This study investigated the consequences of repeated, intermittent social defeat stress on patterns ...
Cross-sensitization between testosterone and cocaine in adolescent and adult rats
(Elsevier B. V., 2015)
Cocaine and anabolic-androgenic steroids are substances commonly co-abused. The use of anabolic steroids and cocaine has increased among adolescents. However, few studies investigated the consequences of the interaction ...
Cocaine - Profiles, drug histories, and patterns of use of patients from Brazil
(Marcel Dekker Inc, 1999-01-01)
We studied profiles and drug histories of 294 cocaine users from 15 treatment services in São Paulo, Brazil during 1996-1997. Mean age of subjects was 27 years, and 90% were male. Over 50% had used five different substances ...
Factors associated with adverse reactions to cocaine among a sample of long-term, high-dose users in São Paulo, Brazil
(Elsevier B.V., 2004-02-01)
This cross-sectional survey investigates the frequency of adverse cocaine reactions and associated factors among regular cocaine misusers. A sample of 332 cocaine misusers from a range of treatment and nontreatment settings ...
Determination of cocaine in samples of hair using the chromatographic column, ISRP-C-18
(Marcel Dekker Inc, 2004-01-01)
A method has been developed for the determination of the cocaine levels in samples of hair, using a chromatographic column internal surface reverse phase (ISRP)-C-18, for direct injection of the extracts of hair, without ...
Determination of cocaine in samples of hair using the chromatographic column, ISRP-C-18
(Marcel Dekker Inc, 2004-01-01)
A method has been developed for the determination of the cocaine levels in samples of hair, using a chromatographic column internal surface reverse phase (ISRP)-C-18, for direct injection of the extracts of hair, without ...
Influence of the dopaminergic system, CREB, and transcription factor-B on cocaine neurotoxicity
(Associação Brasileira de Divulgação Científica (ABRADIC), 2013-11-01)
Cocaine is a widely used drug and its abuse is associated with physical, psychiatric and social problems. Abnormalities in newborns have been demonstrated to be due to the toxic effects of cocaine during fetal development. ...
Cocaine-induced behavioral sensitization is greater in adolescent than in adult mice and heightens cocaine-induced conditioned place preference in adolescents
(Pergamon-Elsevier Science Ltd, 2019-06)
Adolescents are more sensitive than adults to the neural and behavioral effects of psychostimulants, and exhibit greater vulnerability to drug abuse, dependence or relapse into these conditions. We have reported that cocaine ...
GM1 ganglioside enhances the rewarding properties of cocaine in rats
(Elsevier Science, 2010-03-25)
GM1 pretreatment enhanced the rewarding properties of cocaine as assessed in the conditioned place preference paradigm. This effect was shown by the lower dosage of cocaine necessary to induce conditioning compared with ...