Article
The Contribution of Immune Evasive Mechanisms to Parasite Persistence in Visceral Leishmaniasis
Registro en:
FREITAS, E. O. et al. The Contribution of Immune Evasive Mechanisms to Parasite Persistence in Visceral Leishmaniasis. Frontiers in Immunology, v. 7, p. 1-7, 2016
1664-3224
10.3389/fimmu.2016.00153
Autor
Freitas, Elisangela Oliveira de
Leoratti, Fabiana Maria de Souza
Freire-de-Lima, Célio Geraldo
Morrot, Alexandre
Feijó, Daniel Ferreira
Resumen
CNPq e FAPERJ Leishmania is a genus of protozoan parasites that give rise to a range of diseases called Leishmaniasis that affects annually an estimated 1.3 million people from 88 countries. Leishmania donovani and Leishmania (L.) infantum chagasi are responsible to cause the visceral leishmaniasis. The parasite can use assorted strategies to interfere with the host homeostasis to establish persistent infections that without treatment can be lethal. In this review, we highlight the mechanisms involved in the parasite subversion of the host protective immune response and how alterations of host tissue physiology and vascular remodeling during VL could affect the organ-specific immunity against Leishmania parasites.