Article
Preparation and antitubercular activity of lipophilic diamines and amino alcohols
Registro en:
R. JÚNIOR, Celso O. et al. Preparation and antitubercular activity of lipophilic diamines and amino alcohols. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 104, n. 5, p. 703-705, Aug. 2009.
0074-0276
10.1590/S0074-02762009000500006
1678-8060
Autor
R. Júnior, Celso O.
Le Hyaric, Mireille
Costa, Cristiane F. da
Corrêa, Taís A.
Taveira, Aline F.
Araújo, Débora P.
Reis, Elaine F. C.
Lourenço, Maria Cristina S.
Vicente, Felipe R. C.
Almeida, Mauro V. de
Resumen
A series of diamines and amino alcohols derived from 1-dodecanol, 1-tetradecanol, 1,2-dodecanediol and 1,2-tetradecanediol were synthesized and tested for their antitubercular activity. Compounds 3, 8 and 9 were found to be the most active (MIC of 6.25 µg/mL). Nine other compounds displayed activity against Mycobacterium tuberculosis, with a MIC of 12.5 µg/mL.