Preparation and antitubercular activity of lipophilic diamines and amino alcohols

dc.creatorR. Júnior, Celso O.
dc.creatorLe Hyaric, Mireille
dc.creatorCosta, Cristiane F. da
dc.creatorCorrêa, Taís A.
dc.creatorTaveira, Aline F.
dc.creatorAraújo, Débora P.
dc.creatorReis, Elaine F. C.
dc.creatorLourenço, Maria Cristina S.
dc.creatorVicente, Felipe R. C.
dc.creatorAlmeida, Mauro V. de
dc.date2020-01-07T12:18:49Z
dc.date2020-01-07T12:18:49Z
dc.date2009
dc.date.accessioned2023-09-26T23:42:11Z
dc.date.available2023-09-26T23:42:11Z
dc.identifierR. JÚNIOR, Celso O. et al. Preparation and antitubercular activity of lipophilic diamines and amino alcohols. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 104, n. 5, p. 703-705, Aug. 2009.
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/39013
dc.identifier10.1590/S0074-02762009000500006
dc.identifier1678-8060
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8893332
dc.descriptionA series of diamines and amino alcohols derived from 1-dodecanol, 1-tetradecanol, 1,2-dodecanediol and 1,2-tetradecanediol were synthesized and tested for their antitubercular activity. Compounds 3, 8 and 9 were found to be the most active (MIC of 6.25 µg/mL). Nine other compounds displayed activity against Mycobacterium tuberculosis, with a MIC of 12.5 µg/mL.
dc.formatapplication/pdf
dc.languageeng
dc.publisherInstituto Oswaldo Cruz, Ministério da Saúde
dc.rightsopen access
dc.subjectTuberculosis
dc.subjectAmino alcohols
dc.subjectDiamines
dc.subjectLipophilicity
dc.titlePreparation and antitubercular activity of lipophilic diamines and amino alcohols
dc.typeArticle


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