Article
Mycolicibacterium fortuitum genomic epidemiology, resistome and virulome
Registro en:
MORGADO, Sergio et al. Mycolicibacterium fortuitum genomic epidemiology, resistome and virulome. Memórias do instituto Oswaldo Cruz, Rio de Janeiro, v. 116, e210247, p. 1 - 5, Oct. 2021.
0074-0206
1678-8060
Autor
Morgado, Sergio
Ramos, Nilcéia de Veiga
Freitas, Fernanda
Fonseca, Érica Lourenço da
Vicente, Ana Carolina
Resumen
BACKGROUND Mycolicibacterium fortuitum is an opportunistic pathogen associated with human and animal infection worldwide.
Studies concerning this species are mainly represented by case reports, some of them addressing drug susceptibility with a focus
on a specific geographic region, so there is a gap in relation to the global epidemiological scenario.
OBJECTIVES We aimed determine the global epidemiological scenario of M. fortuitum and analyse its traits associated with
pathogenicity.
METHODS Based on publicly available genomes of M. fortuitum and a genome from Brazil (this study), we performed a genomic
epidemiology analysis and in silico and in vitro characterisation of the resistome and virulome of this species.
FINDINGS Three main clusters were defined, one including isolates from the environment, human and animal infections
recovered over nearly a century. An apparent intrinsic resistome comprises mechanisms associated with macrolides, betalactams,
aminoglycosides and antitubercular drugs such as rifampin. Besides, the virulome presented Type VII secretion systems
(T7SS), including ESX-1, ESX-3, ESX-4 and ESX-4-bis, some of which play a role on the virulence of Mycobacteriaceae species.
MAIN CONCLUSIONS Here, M. fortuitum was revealed as a reservoir of an expressive intrinsic resistome, as well as a virulome
that may contribute to its success as a global opportunist pathogen.