Mycolicibacterium fortuitum genomic epidemiology, resistome and virulome

dc.creatorMorgado, Sergio
dc.creatorRamos, Nilcéia de Veiga
dc.creatorFreitas, Fernanda
dc.creatorFonseca, Érica Lourenço da
dc.creatorVicente, Ana Carolina
dc.date2022-02-08T18:54:24Z
dc.date2022-02-08T18:54:24Z
dc.date2021
dc.date.accessioned2023-09-26T23:26:59Z
dc.date.available2023-09-26T23:26:59Z
dc.identifierMORGADO, Sergio et al. Mycolicibacterium fortuitum genomic epidemiology, resistome and virulome. Memórias do instituto Oswaldo Cruz, Rio de Janeiro, v. 116, e210247, p. 1 - 5, Oct. 2021.
dc.identifier0074-0206
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/51096
dc.identifier1678-8060
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8890681
dc.descriptionBACKGROUND Mycolicibacterium fortuitum is an opportunistic pathogen associated with human and animal infection worldwide. Studies concerning this species are mainly represented by case reports, some of them addressing drug susceptibility with a focus on a specific geographic region, so there is a gap in relation to the global epidemiological scenario. OBJECTIVES We aimed determine the global epidemiological scenario of M. fortuitum and analyse its traits associated with pathogenicity. METHODS Based on publicly available genomes of M. fortuitum and a genome from Brazil (this study), we performed a genomic epidemiology analysis and in silico and in vitro characterisation of the resistome and virulome of this species. FINDINGS Three main clusters were defined, one including isolates from the environment, human and animal infections recovered over nearly a century. An apparent intrinsic resistome comprises mechanisms associated with macrolides, betalactams, aminoglycosides and antitubercular drugs such as rifampin. Besides, the virulome presented Type VII secretion systems (T7SS), including ESX-1, ESX-3, ESX-4 and ESX-4-bis, some of which play a role on the virulence of Mycobacteriaceae species. MAIN CONCLUSIONS Here, M. fortuitum was revealed as a reservoir of an expressive intrinsic resistome, as well as a virulome that may contribute to its success as a global opportunist pathogen.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFundação Oswaldo Cruz. Instituto Oswaldo Cruz.
dc.rightsopen access
dc.subjectRifampicina
dc.subjectResistência
dc.subjectSistema de secreção tipo VII
dc.subjectPatógeno oportunista
dc.subjectArr
dc.subjectRifampin
dc.subjectResistance
dc.subjectESX
dc.subjectType VII secretion system
dc.subjectOpportunist pathogen
dc.titleMycolicibacterium fortuitum genomic epidemiology, resistome and virulome
dc.typeArticle


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