Article
Recombination in pe/ppe genes contributes to genetic variation in Mycobacterium tuberculosis lineages
Registro en:
PHELAN, J. E. et al. Recombination in pe/ppe genes contributes to genetic variation in Mycobacterium tuberculosis lineages. BMC Genomics, v. 17, p. 151, 2016.
1471-2164
10.1186/s12864-016-2467-y
Autor
Phelan, Jody E
Coll, Francesc
Bergval, Indra
Anthony, Richard M
Warren, Rob
Sampson, Samantha L
Gey van Pittius, Nicolaas C
Glynn, Judith R
Crampin, Amelia C
Alves, Adriana
Bessa, Theolis Costa Barbosa
Campino, Susana
Dheda, Keertan
Grandjean, Louis
Hasan, Rumina
Hasan, Zahra
Miranda, Anabela
Moore, David
Panaiotov, Stefan
Perdigao, Joao
Portugal, Isabel
Sheen, Patricia
Sousa, Erivelton de Oliveira
Streicher, Elizabeth M
van Helden, Paul D
Viveiros, Miguel
Hibberd, Martin L
Pain, Arnab
McNerney, Ruth
Clark, Taane G
Resumen
Biotechnology and Biological Sciences Research Council Approximately 10% of the Mycobacterium tuberculosis genome is made up of two families of genes that are poorly characterized due to their high GC content and highly repetitive nature. The PE and PPE families are typified by their highly conserved N-terminal domains that incorporate proline-glutamate (PE) and proline-proline-glutamate (PPE) signature motifs. They are hypothesised to be important virulence factors involved with host-pathogen interactions, but their high genetic variability and complexity of analysis means they are typically disregarded in genome studies.